Investigador(a)

Julian Fernandez Ulate

  • Correo electrónico: JULIAN.FERNANDEZULATE@ucr.ac.cr
  • Categoría Regimen Académico: ASOCIADO
  • Grado Académico: DR.
  • Unidad Base: FACULTAD DE MICROBIOLOGÍA

Distinciones

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BECAS

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Publicaciones

Mostrando 50 publicaciones

TÍTULO TIPO FECHA PROYECTO
Skeletal muscle fiber hypercontraction induced by Bothrops asper myotoxic phospholipases A2 ex vivo does not involve a direct action on the contractile apparatus
  • artículo original
2023
Proteomic and toxicological analysis of the venom of Micrurus yatesi and its neutralization by an antivenom
  • artículo original
2022
In vivo neutralization of Myotoxin II, a phospholipase A2 homolog from Bothrops asper venom, using peptides discovered via phage display technology
  • artículo original
2022

No disponible

Solving the microheterogeneity of Bothrops asper myotoxin-II by high-resolution mass spectrometry: insights into C-terminal region variability in Lys49-phospholipase A2 homologs
  • artículo original
2022

No disponible

The recovery from the neuroparalysis caused by Micrurus nigrocinctus venom is accelerated by an agonist of the CXCR4 receptor
  • artículo original
2022

No disponible

Venomics of the poorly studied hognosed pitvipers Porthidium arcosae and Porthidium volcanicum
  • artículo original
2021
The earless monitor lizard Lanthanotus borneensis – a venomous animal?
  • artículo original
2021

No disponible

Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus
  • artículo original
2021
Localization of Myotoxin I and Myotoxin II from the venom of Bothrops asper in a murine model
  • artículo original
2021
Venomics of the Central American Lyre snake Trimorphodon quadruplex (Colubridae: Smith, 1941) from Costa Rica
  • artículo original
2020

No disponible

Comparative biochemical characterization of Viperidae snake venoms from Perú reveals two compositional patterns of phospholipase A2 expression
  • artículo original
2020

No disponible

An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity
  • artículo original
2020

No disponible

Snake venomics, experimental toxic activities and clinical characteristics of human envenomation by Bothrocophias myersi (Serpentes: Viperidae) from Colombia
  • artículo original
2020

No disponible

Enzymatic labelling of venom phospholipase A2 toxins
  • artículo original
2019

No disponible

Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2
  • artículo original
2019
Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)
  • artículo original
2019
Three-finger toxins from the venom of Micrurus tschudii (desert coral snake): isolation and characterization of tschuditoxin-I
  • artículo original
2019
Proteomic profiling, functional characterization, and immunoneutralization of the venom of Porthidium porrasi, a pitviper endemic to Costa Rica
  • artículo original
2019
First look into the venom of Roatan Island´s critically endangered coral snake Micrurus ruatanus: proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom
  • artículo original
2019
Isolation of two basic phospholipases A2 from Bothrops diporus snake venom: comparative characterization and synergism between Asp49 and Lys49 variants
  • artículo original
2019
Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms
  • artículo original
2018

No disponible

Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A2 and mediates its toxic activity
  • artículo original
2018
A myotoxic Lys49 phospholipase A2-homologue is the major component of the venom of Bothrops cotiara from Misiones, Argentina
  • artículo original
2018
Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: functional profile of hemolytic and non-hemolytic isoforms
  • artículo original
2018
A novel pentameric phospholipase A2 myotoxin (PophPLA2) from the venom of the pit viper Porthidium ophryomegas
  • artículo original
2018
Myotoxin-neutralizing peptides
  • patente
2018

No disponible

Venoms of Micrurus coral snakes: evolutionary trends in compositional patterns emerging from proteomic analyses
  • artículo original
2016
Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: proteome, toxicity, and cross-neutralization by antivenom
  • artículo original
2016
Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii
  • artículo original
2016

No disponible

Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest
  • artículo original
2016

No disponible

Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: identification of key toxin targets for antivenom development.
  • artículo original
2015

No disponible

First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis
  • artículo original
2015
Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins
  • artículo original
2015

No disponible

Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids
  • artículo original
2015

No disponible

Venomous snakes of Costa Rica: biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics
  • artículo original
2014
Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo
  • artículo original
2014
Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus
  • artículo original
2014

No disponible

Why myotoxin-containing snake venoms possess powerful nucleotidases?
  • artículo original
2013

No disponible

Amino acid sequence and biological characterization of BlatPLA2, a non-toxic acidic phospholipase A2 from the venom of the arboreal snake Bothriechis lateralis from Costa Rica
  • artículo original
2013
Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A2 myotoxins – distinct mechanisms of action
  • artículo original
2013

No disponible

Implementación de un laboratorio de análisis proteómicos en el Instituto Clodomiro Picado (UCR): primeras experiencias en Costa Rica
  • revista divulgativa
2012

No disponible

Envenomations by Bothrops and Crotalus Snakes Induce the Release of Mitochondrial Alarmins
  • artículo original
2012

No disponible

A Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling
  • artículo original
2012

No disponible

Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: Role of neurotoxic and procoagulant effects in venom toxicity
  • artículo original
2012

No disponible

Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae)
  • artículo original
2011

No disponible

Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: Biochemical and toxicological characterization
  • artículo original
2010

No disponible

Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities
  • artículo original
2010

No disponible

Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose
  • artículo original
2010

No disponible

Snake Venomics and Antivenomics of the Arboreal Neotropical Pitvipers Bothriechis lateralis and Bothriechis schlegelii
  • artículo original
2008

No disponible

Snake Venomics of the Lesser Antillean Pit Vipers Bothrops caribbaeus and Bothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of a Heterologous Antivenom
  • artículo original
2008

No disponible