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Unidad de Investigación
ID: 741
INSTITUTO CLODOMIRO PICADO
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Mostrando 10 proyectos en colaboración
Mostrando 666 publicaciones
TÍTULO | TIPO | AUTOR | PROYECTOS | FECHA |
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Venom of the neotropical rattlesnake, Crotalus culminatus: Intraspecific variation, neutralization by antivenoms, and immunogenicity in rabbits |
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No disponible |
2024 |
Venomics of Leiurus abdullahbayrami, the most lethal scorpion in the Levant region of the Middle East |
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No disponible |
2024 |
Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper |
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No disponible |
2024 |
Toxinological profile and histopathological alterations induced by Bothrocophias campbelli venom from Colombia |
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No disponible |
2024 |
Caracterización de la toxicidad de venenos de serpiente sobre nauplios de Artemia salina y su utilidad para la evaluación de la potencia neutralizante de antivenenos ofídicos. |
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No disponible |
2023 |
SDS‑induced hexameric oligomerization of myotoxin‑II from Bothrops asper assessed by sedimentation velocity and nuclear magnetic resonance |
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No disponible |
2023 |
Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib |
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No disponible |
2023 |
Proteomic analysis of the mandibular glands from the Chinese crocodile lizard, Shinisaurus crocodilurus – another venomous lizard? |
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No disponible |
2023 |
Development of an instrument-free and low-cost ELISA dot-blot test to detect antibodies against SARS-CoV-2 |
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2023 | |
Proteomic profile of the venom of three dark-colored Tityus (Scorpiones: Buthidae) from the tropical rainforests of Costa Rica |
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2023 | |
Clostridium perfringens Phospholipase C, an Archetypal Bacterial Virulence Factor, induces the Formation of Extracellular Traps by Human Neutrophils |
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2023 | |
Skeletal muscle fiber hypercontraction induced by Bothrops asper myotoxic phospholipases A2 ex vivo does not involve a direct action on the contractile apparatus |
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2023 | |
Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: a comprehensive review |
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No disponible |
2023 |
Virulent Brucella nosferati infecting Desmodus rotundus has emerging potential due to the broad foraging range of its bat host for humans and wild and domestic animals |
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2023 | |
Quantification of snake venom proteomes by mass spectrometry-considerations and perspectives. |
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No disponible |
2023 |
Caracterización hidrogeológica del sistema kárstico Gabinarraca-Menonitas-La Higuera en la cuenca de la quebrada El Túnel, Venado de San Carlos, Alajuela, Costa Rica |
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No disponible |
2023 |
Antibodies against a single fraction of Micrurus dumerilii venom neutralize the lethal effect of whole venom |
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No disponible |
2023 |
Discovery and optimization of a broadly-neutralizing human antibody against long-chain α-neurotoxins from snakes |
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No disponible |
2023 |
First insights into the venom composition of two Ecuadorian coral snakes |
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No disponible |
2022 |
In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom. |
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No disponible |
2022 |
Proteomic and toxicological analysis of the venom of Micrurus yatesi and its neutralization by an antivenom |
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2022 | |
In vivo neutralization of Myotoxin II, a phospholipase A2 homolog from Bothrops asper venom, using peptides discovered via phage display technology |
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No disponible |
2022 |
In vitro Characterization of Anti-SARS-CoV-2 Intravenous Immunoglobulins (IVIg) Produced From Plasma of Donors Immunized With the BNT162b2 Vaccine and Its Comparison With a Similar Formulation Produced From Plasma of COVID-19 Convalescent Donors |
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2022 | |
Welfare assessment of horses ridden in the Costa Rica National Horse Parade |
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No disponible |
2022 |
Solving the microheterogeneity of Bothrops asper myotoxin-II by high-resolution mass spectrometry: insights into C-terminal region variability in Lys49-phospholipase A2 homologs |
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No disponible |
2022 |
The recovery from the neuroparalysis caused by Micrurus nigrocinctus venom is accelerated by an agonist of the CXCR4 receptor |
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No disponible |
2022 |
Half a century of research on Bothrops asper venom variation: biological and biomedical implications |
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No disponible |
2022 |
Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats |
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No disponible |
2022 |
Venomics of the scorpion Tityus ocelote (Scorpiones, Buthidae): Understanding venom evolution in the subgenus Archaeotityus |
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2022 | |
In vivo treatment with varespladib, a phospholipase A2 inhibitor, prevents the peripheral neurotoxicity and systemic disorders induced by Micrurus corallinus (coralsnake) venom in rats |
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No disponible |
2022 |
Proteomic and toxicological characterization of the venoms of the most enigmatic group of rattlesnakes: The long-tailed rattlesnakes |
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No disponible |
2022 |
Molecular architecture of the antiophidic protein DM64 and its binding specificity to myotoxin II from Bothrops asper venom |
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No disponible |
2022 |
What’s in a mass |
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No disponible |
2021 |
The synthetic Varespladib molecule is a multi-functional inhibitor for PLA2 and PLA2-like ophidic toxins |
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No disponible |
2021 |
The earless monitor lizard Lanthanotus borneensis – a venomous animal? |
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No disponible |
2021 |
Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19 |
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2021 | |
Venomics of the poorly studied hognosed pitvipers Porthidium arcosae and Porthidium volcanicum |
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2021 |
Cardiac effect induced by Crotalus durissus cascavella venom: morphofunctional evidence and mechanism of action |
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No disponible |
2021 |
Effect on cell growth, viability and migration of geraniol and geraniol-containing essential oil from Lippia alba (Verbenaceae) on gastric carcinoma cells |
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2021 | |
Importance of mevalonate pathway lipids on the growth and survival of primary and metastatic gastric carcinoma cells |
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2021 | |
Promoting co-existence between humans and venomous snakes through increasing the herpetological knowledge base |
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No disponible |
2021 |
Assessing a 6-h endpoint observation time in the lethality neutralization assay used to evaluate the preclinical efficacy of snake antivenoms |
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2021 | |
Anexo 5: Guías de la OMS para la producción, control y regulación de inmunoglobulinas antiveneno de serpiente |
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No disponible |
2021 |
Localization of Myotoxin I and Myotoxin II from the venom of Bothrops asper in a murine model |
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2021 | |
Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance |
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No disponible |
2021 |
Antivenomics and in vivo preclinical efficacy of six Latin American antivenoms towards south-western Colombian Bothrops asper lineage venoms |
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No disponible |
2021 |
Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus |
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2021 | |
High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern |
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2021 | |
Venom variation in Bothrops asper lineages from north-western South America. |
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No disponible |
2020 |
Danger in the canopy: comparative proteomics and bioactivities of the venoms of the South American palm viper Bothrops bilineatus subspecies bilineatus and smaragdinus, and antivenomics of B. b. bilineatus (Rondônia) venom against the Brazilian pentabothropic antivenom |
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No disponible |
2020 |
Editorial: Novel immunotherapies against envenomings by snakes and other venomous animals |
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No disponible |
2020 |
Development of nanobodies against hemorrhagic and myotoxic components of Bothrops atrox snake venom |
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No disponible |
2020 |
Venom diversity in the neotropical genus Tityus: implications for antivenom design emerging from molecular and immunochemical analyses across endemic areas of scorpionism |
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No disponible |
2020 |
A lipidomic perspective of the action of group IIA secreted phospholipase A2 on human monocytes: lipid droplet biogenesis and activation of cytosolic phospholipase A2α |
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No disponible |
2020 |
12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages |
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No disponible |
2020 |
Venomics of the Duvernoy's gland secretion of the false coral snake Rhinobothryum bovallii (Andersson, 1916) and assessment of venom lethality towards synapsid and diapsid animal models |
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No disponible |
2020 |
Potent virucidal activity against Flaviviridae of a group IIA phospholipase A2 isolated from the venom of Bothrops asper |
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2020 | |
Snake venomics, experimental toxic activities and clinical characteristics of human envenomation by Bothrocophias myersi (Serpentes: Viperidae) from Colombia |
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No disponible |
2020 |
Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni browni: identification of the first lethal multimeric neurotoxin in coral snake venom |
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No disponible |
2020 |
Manual de Métodos Inmunológicos |
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No disponible |
2020 |
Comparative biochemical characterization of Viperidae snake venoms from Perú reveals two compositional patterns of phospholipase A2 expression |
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No disponible |
2020 |
Preadipocytes are target cells for the actions of a representative gIIA phospholipase A2 which triggers proinflammatory pathways related to obesity |
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No disponible |
2020 |
An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity |
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No disponible |
2020 |
Unity makes strength: exploring intra and interspecies toxin synergism between phospholipases A2 and cytotoxins |
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No disponible |
2020 |
Immunological cross-recognition and neutralization studies of Micrurus mipartitus and Micrurus dumerilii venoms by two therapeutic equine antivenoms |
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2020 | |
Oral administration of Costa Rican guava (Psidium friedrichsthalianum) juice induces changes in urinary excretion of energy-related compounds in Wistar rats determined by 1H NMR |
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2020 | |
Novel snakebite therapeutics must be tested in appropriate rescue models to robustly assess their preclinical efficacy |
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No disponible |
2020 |
Tratamientos COVID-19 |
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No disponible |
2020 |
Ontogenetic variation in the venom of Mexican Jumping Viper (Metlapilcoatlus nummifer) |
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No disponible |
2020 |
Métodos de Investigación: destrezas básicas para el trabajo científico en las disciplinas biomédicas |
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No disponible |
2020 |
Venomics of the Central American Lyre snake Trimorphodon quadruplex (Colubridae: Smith, 1941) from Costa Rica |
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No disponible |
2020 |
Proteogenomic analysis of the Clostridium difficile exoproteome reveals a correlation between phylogenetic distribution and virulence potential |
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2020 | |
Varespladib (LY315920) and methyl Varespladib (LY333013) abrogate or delay lethality induced by presynaptically-acting neurotoxic snake venoms |
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No disponible |
2020 |
Genetic and toxinological divergence among populations of Tityus trivittatus Kraepelin, 1898 (Scorpiones: Buthidae) inhabiting Paraguay and Argentina |
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No disponible |
2020 |
Mevalonate pathway as a novel target for the treatment of metastatic gastric cancer |
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2020 |
Reflexiones desde la academia. Universidad, ciencia y sociedad |
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No disponible |
2019 |
Novel three-finger toxins from Micrurus dumerilii and Micrurus mipartitus coral snake venoms: phylogenetic relationships and characterization of Clarkitoxin-I-Mdum |
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2019 | |
Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2 |
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2019 | |
First look into the venom of Roatan Island´s critically endangered coral snake Micrurus ruatanus: proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom |
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2019 | |
Biochemical characterization of the venom of Central American scorpion Didymocentrus krausi Francke, 1978 (Diplocentridae) and its toxic effects in vivo and in vitro |
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2019 | |
Venom characterization of the bark scorpion Centruroides edwardsii (Gervais 1843): composition, biochemical activities and in vivo toxicity for potential prey |
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2019 | |
Enzymatic labelling of venom phospholipase A2 toxins |
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No disponible |
2019 |
Physical characteristics of nano-Hydroxyapatite Pickering-emulsions and their adjuvant activity on the antibody response towards the Bothros asper snake venom |
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No disponible |
2019 |
Proteomic profiling, functional characterization, and immunoneutralization of the venom of Porthidium porrasi, a pitviper endemic to Costa Rica |
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2019 | |
Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species |
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2019 | |
Isolation of two basic phospholipases A2 from Bothrops diporus snake venom: comparative characterization and synergism between Asp49 and Lys49 variants |
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2019 | |
Brazil nut intake increases circulating miR-454-3p and miR-584-5p in obese women |
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No disponible |
2019 |
New insights into the phylogeographic distribution of the 3FTx/PLA2 venom dichotomy across genus Micrurus in South America |
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2019 | |
Caracterización proteómica, funcional e inmunoneutralización del veneno de la serpiente Porthidium porrasi de Costa Rica |
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No disponible |
2019 |
A secreted phospholipase A2 induces formation of smooth muscle foam cells which trans-differentiate to macrophage-like state |
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No disponible |
2019 |
Three-finger toxins from the venom of Micrurus tschudii (desert coral snake): isolation and characterization of tschuditoxin-I |
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2019 | |
Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920) |
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2019 | |
Venom characterization of the three species of Ophryacus and proteomic profiling of O. sphenophrys unveils Sphenotoxin, a novel Crotoxin-like heterodimeric β-neurotoxin |
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No disponible |
2019 |
Differences in plasmatic butyrylcholinesterases (BChE) values between Pacific and Caribbean populations of terciopelo (Bothrops asper) in Costa Rica |
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2019 | |
Cloning, purification and characterization of nigrelysin, a novel actinoporin from the sea anemone Anthopleura nigrescens |
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No disponible |
2019 |
Delayed oral LY333013 rescues mice from highly neurotoxic, lethal doses of Papuan Taipan (Oxyuranus scutellatus) venom |
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No disponible |
2018 |
Prolonged development of the middle ear in Rhinella horribilis |
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No disponible |
2018 |
MipLAAO, a new L-amino acid oxidase from the redtail coral snake, Micrurus mipartitus |
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2018 | |
Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: functional profile of hemolytic and non-hemolytic isoforms |
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2018 | |
Myotoxin-neutralizing peptides |
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No disponible |
2018 |
Innovative immunization strategies for antivenom development |
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No disponible |
2018 |
Biological and proteolytic variation in the venom of Crotalus scutulatus scutulatus from Mexico |
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No disponible |
2018 |
Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A2 and mediates its toxic activity |
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2018 | |
A novel pentameric phospholipase A2 myotoxin (PophPLA2) from the venom of the pit viper Porthidium ophryomegas |
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2018 | |
Nociones de Inmunologia |
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No disponible |
2018 |
A myotoxic Lys49 phospholipase A2-homologue is the major component of the venom of Bothrops cotiara from Misiones, Argentina |
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2018 | |
Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus |
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2018 | |
In vivo neutralization of the dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG monoclonal antibodies |
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No disponible |
2018 |
Pros and cons of different therapeutic antibody formats for recombinant antivenom development |
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No disponible |
2018 |
A snake venom secreted phospholipase A2 induces foam cell formation depending on the activation of factors involved in lipid homeostasis |
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No disponible |
2018 |
Effect of exposition to chlorpyrifos upon plasmatic cholinesterases, hematology and blood biochemistry values in Bothrops asper (Serpentes: Viperidae) |
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2018 | |
Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms |
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No disponible |
2018 |
Cannibalism by large tadpoles of Rhinophrynus dorsalis (Anura: Rhinophrynidae) |
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No disponible |
2018 |
Depletion of complement enhances the clearance of Brucella abortus in mice |
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2018 | |
Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms |
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No disponible |
2017 |
Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead |
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No disponible |
2017 |
Geographical variability of the venoms of four populations of Bothrops asper from Panama: Toxicological analysis and neutralization by a polyvalent antivenom |
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No disponible |
2017 |
Pitfalls to avoid when using phage display for snake toxins |
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No disponible |
2017 |
Primary structures and partial toxicological characterization of two phospholipases A2 from Micrurus mipartitus and Micrurus dumerilii coral snake venoms |
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2017 | |
Comparison of biochemical and cytotoxic activities of extracts obtained from dorsal spines and caudal fin of adult and juvenile non-native Caribbean lionfish (Pterois volitans/miles) |
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2017 | |
Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping |
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No disponible |
2017 |
Physicochemical characterization of Jicaro seeds (Crescentia alata H.B.K.): a novel protein-rich and oleaginous seed |
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No disponible |
2017 |
Epidemiology of bovine brucellosis in Costa Rica: Lessons learned from failures in the control of the disease |
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No disponible |
2017 |
Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect |
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No disponible |
2017 |
Detection of a synthetic sex steroid in the American crocodile (Crocodylus acutus): Evidence for a novel environmental androgen |
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2017 | |
Proteomic analysis of venom variability and ontogeny across the arboreal palm-pitvipers (genus Bothriechis) |
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No disponible |
2017 |
Brucellosis caused by the wood rat pathogen Brucella neotomae: two case reports |
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No disponible |
2017 |
Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus |
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No disponible |
2017 |
Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca |
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No disponible |
2017 |
Crystal structure of a phospholipase A2 from Bothrops asper venom: Insights into a new putative “myotoxic cluster” |
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No disponible |
2017 |
Proteoform-resolved quantitative venomics: looking through a crystal ball |
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No disponible |
2017 |
Screening for target toxins of the antiophidic protein DM64 through a gel-based interactomics approach |
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No disponible |
2017 |
High-density peptide microarray exploration of the antibody response in a rabbit immunized with a neurotoxic venom fraction |
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No disponible |
2017 |
Comparison of the adjuvant activity of emulsions with different physicochemical properties on the antibody response towards the venom of West African carpet viper (Echis ocellatus) |
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2017 | |
Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab0)2 and whole IgG antivenoms |
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No disponible |
2016 |
Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains |
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No disponible |
2016 |
High-throughput immuno-profiling of mamba (Dendroaspis) venom toxin epitopes using high-density peptide microarrays |
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No disponible |
2016 |
Desarrollo de la herpetocultura en Costa Rica: Situación actual de herpetarios y manejo ex situ de reptiles y anfibios |
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No disponible |
2016 |
Venomic analysis of the poorly studied desert coral snake, Micrurus tschudii tschudii, supports the 3FTx/PLA2 dichotomy across Micrurus venoms |
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No disponible |
2016 |
Methyltestosterone alters sex determination in the American alligator (Alligator mississippiensis) |
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No disponible |
2016 |
Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps). |
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No disponible |
2016 |
Venoms of Micrurus coral snakes: evolutionary trends in compositional patterns emerging from proteomic analyses |
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2016 | |
Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: proteome, toxicity, and cross-neutralization by antivenom |
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2016 | |
From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy |
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No disponible |
2016 |
Metaloproteinasas dependientes de Zinc: Protagonistas centrales en la Fisiopatología de Envenenamientos por Serpientes de la familia Viperidae |
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No disponible |
2016 |
Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: A biochemical and immunohistochemical study |
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No disponible |
2016 |
Mecanismo de açao dos venenos de cobras corais |
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No disponible |
2016 |
Actividad letal de seis venenos de serpientes de importancia médica en el Ecuador |
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No disponible |
2016 |
Understanding and confronting snakebite envenoming: The harvest of cooperation |
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No disponible |
2016 |
Larval aggression is independent of food limitation in nurseries of a poison frog |
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No disponible |
2016 |
Hemorrhage Caused by Snake Venom Metalloproteinases: A Journey of Discovery and Understanding |
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No disponible |
2016 |
Hydrology Affects Environmental and Spatial Structuring of Microalgal Metacommunities in Tropical Pacific Coast Wetlands |
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2016 | |
Venom of the Coral Snake Micrurus clarki: Proteomic Profile, Toxicity, Immunological Cross-Neutralization, and Characterization of a Three-Finger Toxin |
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No disponible |
2016 |
Novel catalytically-inactive PII metalloproteinases from a viperid snake venom with substitutions in the canonical zinc-binding motif |
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2016 | |
N-terminal peptide of myotoxin II from Bothrops asper venom enhances the activity of endothelin converting enzyme and neprilysin |
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No disponible |
2016 |
Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: An experimental study in mice |
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No disponible |
2016 |
Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii |
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No disponible |
2016 |
A cryptic palm-pitviper species (Squamata: Viperidae: Bothriechis) from the Costa Rican highlands, with notes on the variation within B. nigroviridis |
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No disponible |
2016 |
Divergent functional profiles of acidic and basic phospholipases A2 in the venom of the snake Porthidium lansbergii lansbergii |
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2016 | |
Regional warming and the thermal regimes of American crocodile nests in the Tempisque Basin, Costa Rica |
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No disponible |
2016 |
Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest |
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No disponible |
2016 |
Bacterial Sphingomyelinases and Phospholipases as Virulence Factors |
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2016 | |
Lemnitoxin, the major component of Micrurus lemniscatus coral snake venom, is a myotoxic and pro-inflammatory phospholipase A2 |
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No disponible |
2016 |
Preclinical evaluation of three polyspecific antivenoms against the venom of Echis ocellatus: Neutralization of toxic activities and antivenomics |
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No disponible |
2016 |
Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis |
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No disponible |
2016 |
Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom |
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No disponible |
2016 |
The need for an integrated approach in confronting snakebite envenoming in Latin America: the relevance of endogenous scientific and technological research |
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No disponible |
2016 |
Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage |
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No disponible |
2015 |
Seasonal wetlands in the Pacific coast of Costa Rica and Nicaragua: environmental characterisation and conservation status |
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2015 | |
Multiple paths to aquatic specialisation in four species of Central American Anolis lizards |
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No disponible |
2015 |
Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: identification of key toxin targets for antivenom development. |
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No disponible |
2015 |
Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil |
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No disponible |
2015 |
Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins |
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No disponible |
2015 |
Phospholipase A2 enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis |
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2015 | |
Proteomic and functional analysis of the venom of Porthidium lansbergii lansbergii (Lansberg’s hognose viper) from the Atlantic Department of Colombia |
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No disponible |
2015 |
Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors |
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No disponible |
2015 |
Assessing endotoxins in equine-derived snake antivenoms: Comparison of the USP pyrogen test and the Limulus Amoebocyte Lysate assay (LAL) |
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2015 | |
Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step |
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2015 | |
Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids |
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No disponible |
2015 |
Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide |
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No disponible |
2015 |
Improved biomass and protein production in solid-state cultures of an Aspergillus sojae strain harboring the Vitreoscilla hemoglobin |
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No disponible |
2015 |
Phospholipases a2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms |
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No disponible |
2015 |
A constant area monolayer method to assess optimal lipid packing for lipolysis tested with several secreted phospholipases A2 |
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2015 | |
Antivenomics: a proteomics tool for studying the immunoreactivity of antivenoms |
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2015 | |
Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: Insights from a Model with Extract Administration before Venom Injection |
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No disponible |
2015 |
A Call for Incorporating Social Research in the Global Struggle against Snakebite |
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No disponible |
2015 |
Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score |
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No disponible |
2015 |
Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis |
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No disponible |
2015 |
Minipool Caprylic Acid Fractionation of Plasma Using Disposable Equipment: A Practical Method to Enhance Immunoglobulin Supply in Developing Countries |
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No disponible |
2015 |
Brucella canis Is an Intracellular Pathogen That Induces a Lower Proinflammatory Response than Smooth Zoonotic Counterparts |
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2015 | |
Índices bibliométricos y revistas de ‘corriente central’: implicaciones para el desarrollo de las ciencias naturales en Costa Rica |
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No disponible |
2015 |
The lethality test used for estimating the potency of antivenoms against Bothrops asper snake venom: Pathophysiological mechanisms, prophylactic analgesia, and a surrogate in vitro assay |
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2015 | |
Evaluation of the preclinical efficacy of four antivenoms, distributed in sub-Saharan Africa, to neutralize the venom of the carpet viper, Echis ocellatus, from Mali, Cameroon, and Nigeria |
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No disponible |
2015 |
Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom |
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2015 | |
Snakebites are associated with poverty, weather fluctuations, and El Niño |
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No disponible |
2015 |
Membrane-damaging and cytotoxic sphingomyelinases and phospholipases |
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No disponible |
2015 |
First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis |
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2015 | |
MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity |
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No disponible |
2015 |
A bright future for integrative venomics |
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No disponible |
2015 |
Group-II phospholipase A2 enzymes |
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No disponible |
2015 |
Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms |
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No disponible |
2015 |
Snake venomics of Bothrops punctatus, a semi-arboreal pitviper species from Antioquia, Colombia |
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No disponible |
2014 |
Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica |
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No disponible |
2014 |
Proteomic and toxicological profiling of the venom of Bothrocophias campbelli, a pitviper species from Ecuador and Colombia |
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2014 | |
Current challenges for confronting the public health problem of snakebite envenoming in Central America |
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No disponible |
2014 |
Critical role of TLR2 and MyD88 for functional response of macrophages to a group IIA-Secreted phospholipase A2 from snake venom |
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No disponible |
2014 |
Anticomplementary Activity of Horse IgG and F(ab’)2 Antivenoms |
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No disponible |
2014 |
Reducing the impact of snakebite envenoming in Latin America and the Caribbean: achievements and challenges ahead |
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No disponible |
2014 |
Utilidad de los péptidos sintéticos en estudios de estructura-función e identificación de epitopos en toxinas |
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No disponible |
2014 |
Omics Meets Biology: Application to the Design and Preclinical Assessment of Antivenoms |
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No disponible |
2014 |
Tissue Damage and Inflammation Induced by Snake Venoms |
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No disponible |
2014 |
Snakebite Envenomingin Latin America and the Caribbean |
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No disponible |
2014 |
Epidemiology of rapes in Costa Rica: Characterization of victims, perpetrators and circumstances surrounding forced intercourse |
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No disponible |
2014 |
A multicomponent strategy to improve the availability of antivenom for treating snakebite envenoming |
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No disponible |
2014 |
Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays |
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No disponible |
2014 |
Intravascular hemolysis induced by the venom of the Eastern coral snake, Micrurus fulvius, in a mouse model: Identification of directly hemolytic phospholipases A2 |
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No disponible |
2014 |
Antivenomic Characterization of Two Antivenoms Against the Venom of the Taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia |
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No disponible |
2014 |
Industrial Production and Quality Control of Snake Antivenoms |
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No disponible |
2014 |
Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus |
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No disponible |
2014 |
Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo |
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2014 | |
Preclinical efficacy of Australian antivenoms against the venom of the small-eyed snake, Micropechis ikaheka, from Papua New Guinea: An antivenomics and neutralization study |
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2014 | |
Venomous snakes of Costa Rica: biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics |
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2014 | |
The analgesics morphine and tramadol do not alter the acute toxicity induced by Bothrops asper snake venom in mice |
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No disponible |
2014 |
Role of enzymatic activity inmuscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved? |
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No disponible |
2014 |
Evidence of maternal provisioning of alkaloid-based chemical defenses in the strawberry poison frog Oophaga pumilio |
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No disponible |
2014 |
Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: Comparison of their stability in an accelerated test |
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No disponible |
2014 |
Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom |
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2014 | |
A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom |
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No disponible |
2014 |
Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom |
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No disponible |
2014 |
Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation |
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2014 | |
Understanding structural and functional aspects of PII snake venom metalloproteinases: Characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis |
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No disponible |
2014 |
Two color morphs of the pelagic yellow-bellied sea snake, pelamis platura, from different locations of Costa Rica: snake venomics, toxicity, and neutralization by antivenom |
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2014 | |
An Asp49 Phospholipase A2 from Snake Venom Induces Cyclooxygenase-2 Expression and Prostaglandin E2 Production via Activation of NF-κB, p38MAPK, and PKC in Macrophages |
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No disponible |
2014 |
Venomics of new world pit vipers: genus-wide comparisons of venom proteomes across Agkistrodon |
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2014 | |
Combined venom gland cDNA sequencing and venomics of the New Guinea small-eyed snake, Micropechis ikaheka |
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2014 | |
A structure-based proposal for a comprehensive myotoxic mechanism of phospholipase A2-like proteins from viperid snake venoms |
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No disponible |
2014 |
Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis |
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No disponible |
2013 |
The Need for Full Integration of Snakebite Envenoming within a Global Strategy to Combat the Neglected Tropical Diseases: The Way Forward |
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No disponible |
2013 |
Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase |
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No disponible |
2013 |
Instituto Clodomiro Picado |
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No disponible |
2013 |
Phospholipases A2: Unveiling the secrets of a functionally versatile group of snake venom toxins |
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No disponible |
2013 |
Role of the animal model on the pharmacokinetics of equine-derived antivenoms |
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No disponible |
2013 |
Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model |
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No disponible |
2013 |
Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics |
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No disponible |
2013 |
Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom |
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No disponible |
2013 |
Algoritmo para el diagnóstico y tratamiento con antivenenos en pacientes mordidos por serpientes en Centroamérica |
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No disponible |
2013 |
Tratamiento hospitalario del envenenamiento por mordedura de serpiente |
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No disponible |
2013 |
A Lys49 Phospholipase A2, Isolated from Bothrops asper Snake Venom, Induces Lipid Droplet Formation in Macrophages Which Depends on Distinct Signaling Pathways and the C-Terminal Region |
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No disponible |
2013 |
Integrated “omics” profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus |
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No disponible |
2013 |
A catalytically-inactive snake venom Lys49 phospholipase A2 homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages |
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No disponible |
2013 |
Generalidades de serpientes venenosas en Costa Rica |
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No disponible |
2013 |
New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India |
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No disponible |
2013 |
Guía de información: Serpientes de Costa Rica y prevención de mordeduras |
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No disponible |
2013 |
Suero antiofídico anti-coral |
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No disponible |
2013 |
Suero antiofidico polivalente |
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No disponible |
2013 |
Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and neutralization assays |
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No disponible |
2013 |
Antivenom for snakebite envenoming in Sri Lanka: The need for geographically specific antivenom and improved efficacy |
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No disponible |
2013 |
Why myotoxin-containing snake venoms possess powerful nucleotidases? |
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No disponible |
2013 |
Amino acid sequence and biological characterization of BlatPLA2, a non-toxic acidic phospholipase A2 from the venom of the arboreal snake Bothriechis lateralis from Costa Rica |
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2013 | |
Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico |
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No disponible |
2013 |
Intraspecies variation in the venom of the rattlesnake Crotalus simus from Mexico: Different expression of crotoxin results in highly variable toxicity in the venoms of three subspecies |
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No disponible |
2013 |
Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms |
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No disponible |
2013 |
Investigación colaborativa, generación de redes y coautoría de publicaciones: un estudio de caso del Instituto Clodomiro Picado |
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No disponible |
2013 |
Using Geographical Information Systems to Identify Populations in Need of Improved Accessibility to Antivenom Treatment for Snakebite Envenoming in Costa Rica |
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No disponible |
2013 |
Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture |
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No disponible |
2013 |
Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A2 myotoxins – distinct mechanisms of action |
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No disponible |
2013 |
Polyspecific Antivenom Liquid |
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No disponible |
2013 |
An acidic phospholipase A2 with antibacterial activity from Porthidium nasutum snake venom |
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No disponible |
2012 |
Identification of New Snake Venom Metalloproteinase Inhibitors Using Compound Screening and Rational Peptide Design |
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No disponible |
2012 |
Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: Keys to understand the variable immune response in horses |
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No disponible |
2012 |
Identification of linear B-cell epitopes on myotoxin-II, a Lys49 phospholipase A2 homologue from Bothrops asper snake venom |
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2012 | |
Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica |
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No disponible |
2012 |
Antiplasmodial effect of the venom of Crotalus durissus cumanensis, crotoxin complex and Crotoxin B |
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No disponible |
2012 |
Venom of Bothrops asper from Mexico and Costa Rica: Intraspecific variation and cross-neutralization by antivenoms |
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2012 | |
Snake venom Lys49 myotoxins: from phospholipases A2 to non-enzymatic membrane disruptors |
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2012 | |
La situación de los antivenenos liofilizados en América Latina: Aspectos tecnológicos y de salud pública |
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No disponible |
2012 |
Venenos de serpiente: de la investigación al tratamiento |
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No disponible |
2012 |
Second generation snake antivenomics: Comparing immunoaffinity and immunodepletion protocols |
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No disponible |
2012 |
Efficacy of IgG and F(ab′)2 Antivenoms to Neutralize Snake Venom-induced Local Tissue Damage as Assessed by the Proteomic Analysis of Wound Exudate |
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2012 | |
Improving antivenom availability and accessibility: Science, technology, and beyond |
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No disponible |
2012 |
Implementación de un laboratorio de análisis proteómicos en el Instituto Clodomiro Picado (UCR): primeras experiencias en Costa Rica |
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No disponible |
2012 |
Low pH formulation of whole IgG antivenom: Impact on quality, safety, neutralizing potency and viral inactivation |
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No disponible |
2012 |
Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab0)2] antivenoms, in Bothrops asper bites in Colombia |
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No disponible |
2012 |
Resurrexit, sicut dixit, alleluia. Snake venomics from a 26-years old polyacrylamide focusing gel |
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No disponible |
2012 |
Envenomations by Bothrops and Crotalus Snakes Induce the Release of Mitochondrial Alarmins |
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No disponible |
2012 |
Mipartoxin-I, a novel three-finger toxin, is the major neurotoxic component in the venom of the redtail coral snake Micrurus mipartitus (Elapidae) |
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2012 | |
Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: Toxicological and taxonomical insights |
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No disponible |
2012 |
Inversión en ciencia, tecnología e innovación: proyectando a Costa Rica |
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No disponible |
2012 |
Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: Role of neurotoxic and procoagulant effects in venom toxicity |
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No disponible |
2012 |
Purification of IgG and albumin from human plasma by aqueous two phase system fractionation |
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No disponible |
2012 |
Investigación científica y tecnológica en el Instituto Clodomiro Picado: Una perspectiva bibliométrica de cuatro décadas (1970-2010) |
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No disponible |
2012 |
A Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling |
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No disponible |
2012 |
To beg or to freeze: multimodal sensory integration directs behavior in a tadpole |
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No disponible |
2012 |
Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom |
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No disponible |
2012 |
Snake venomics of crotalus tigris: the minimalist toxin arsenal of the deadliest neartic rattlesnake venom: evolutionary clues for generating a pan-specific antivenom against crotalid type II venoms |
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No disponible |
2012 |
A group IIA-secreted phospholipase A2 from snake venom induces lipid body formation in macrophages: the roles of intracellular phospholipases A2 and distinct signaling pathways |
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No disponible |
2011 |
Differences in escape behavior between a cryptic and an aposematic litter frog |
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No disponible |
2011 |
High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry |
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No disponible |
2011 |
Método para la producción de formulaciones inyectables de productos proteicos hemoderivados y productos obtenidos utilizando dicho método |
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2011 | |
Proteomics of Wound Exudate in Snake Venom-Induced Pathology: Search for Biomarkers To Assess Tissue Damage and Therapeutic Success |
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No disponible |
2011 |
A phospholipase A2 from Bothrops asper snake venom activates neutrophils in culture: Expression of cyclooxygenase-2 and PGE2 biosynthesis |
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No disponible |
2011 |
Antivenoms for the treatment of snakebite envenomings: The road ahead |
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No disponible |
2011 |
Poor regenerative outcome after skeletal muscle necrosis induced by Bothrops asper venom: alterations in microvasculature and nerves |
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2011 | |
Immune Response Towards Snake Venoms |
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2011 | |
Phospholipases A2 From Viperidae Snake Venoms: How do They Induce Skeletal Muscle Damage? |
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No disponible |
2011 |
Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom |
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2011 | |
Ending the drought: New strategies for improving the flow of affordable, effective antivenoms in Asia and Africa |
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No disponible |
2011 |
Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management |
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No disponible |
2011 |
Desarrollo de las universidades públicas de Latinoamérica: una visión alternativa al modelo economicista de rentabilidad |
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No disponible |
2011 |
Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae) |
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No disponible |
2011 |
Preclinical evaluation of caprylic-acid fractionated IgG antivenom for the treatment of taipan (Oxyuranus scutellatus) envneoming in Papua New Guinea |
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No disponible |
2011 |
Envenenamientos por mordeduras de serpientes en América Latina y el Caribe: Una visión integral de carácter regional |
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No disponible |
2011 |
Antivenoms for Snakebite Envenomings |
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No disponible |
2011 |
Proteomic and biological characterization of the venom of the redtail coral snake, Micrurus mipartitus (Elapidae), from Colombia and Costa Rica |
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2011 | |
Membrane cholesterol modulates the cytolytic mechanism of myotoxin II, a Lys49 phospholipase A2 homologue from the venom of Bothrops asper |
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No disponible |
2011 |
Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases |
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2011 | |
Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenoms |
|
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2011 | |
Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing |
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No disponible |
2011 |
Snake Venomics of African Spitting Cobras: Toxin Composition and Assessment of Congeneric Cross-Reactivity of the Pan-African EchiTAb-Plus-ICP Antivenom by Antivenomics and Neutralization Approaches |
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2011 | |
Venenos de serpientes de la familia Viperidae en América: Bioquímica y fisiopatología. |
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No disponible |
2011 |
Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases |
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No disponible |
2011 |
The C-terminal region of a Lys49 myotoxin mediates Ca2þ influx in C2C12 myotubes |
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No disponible |
2010 |
Immunochemical and biological characterization of monoclonal antibodies against BaP1, a metalloproteinase from Bothrops asper snake venom |
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No disponible |
2010 |
Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective? |
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No disponible |
2010 |
Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain |
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No disponible |
2010 |
Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic Trend along Crotalus Dispersal in South America |
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No disponible |
2010 |
Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa |
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No disponible |
2010 |
The Global Snake Bite Initiative: an antidote for snake bite |
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No disponible |
2010 |
Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom |
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No disponible |
2010 |
Acute physiopathological effects of honeybee (Apis mellifera) envenoming by subcutaneous route in a mouse model |
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No disponible |
2010 |
Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities |
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No disponible |
2010 |
Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose |
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No disponible |
2010 |
Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms |
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No disponible |
2010 |
Backbone Flexibility Controls the Activity and Specificity of a Protein−Protein Interface: Specificity in Snake Venom Metalloproteases |
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No disponible |
2010 |
Snakebite envenoming from a global perspective: Towards an integrated approach |
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No disponible |
2010 |
Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: Biochemical and toxicological characterization |
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No disponible |
2010 |
Dr. Clodomiro Picado Twight (1887-1944) |
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No disponible |
2010 |
Impact of Regional Variation in Bothrops asper Snake Venom on the Design of Antivenoms: Integrating Antivenomics and Neutralization Approaches |
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No disponible |
2010 |
Antivenomic Assessment of the Immunological Reactivity of EchiTAb-Plus-ICP, an Antivenom for the Treatment of Snakebite Envenoming in Sub-Saharan Africa |
|
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No disponible |
2010 |
Neutralization of Bothrops mattogrossensis snake venom from Bolivia: Experimental evaluation of llama and donkey antivenoms produced by caprylic acid precipitation |
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No disponible |
2010 |
Synthetic peptides derived from the C-terminal region of Lys49 phospholipase A2 homologues from Viperidae snake venoms: biomimetic activities and potential applications |
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No disponible |
2010 |
Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows |
|
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No disponible |
2010 |
Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism |
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No disponible |
2009 |
Mortality by Hymenoptera stings in Costa Rica, 1985-2006 |
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No disponible |
2009 |
Stability of equine IgG antivenoms obtained by caprylic acid precipitation: Towards a liquid formulation stable at tropical room temperature |
|
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No disponible |
2009 |
Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom |
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No disponible |
2009 |
Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming |
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No disponible |
2009 |
The Phospholipase A2 Homologues of Snake Venoms: Biological Activities and Their Possible Adaptive Roles |
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No disponible |
2009 |
High-Resolution Crystal Structure of the Snake Venom Metalloproteinase BaP1 Complexed with a Peptidomimetic: Insight into Inhibitor Binding |
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No disponible |
2009 |
Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors |
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No disponible |
2009 |
Hacia una mayor integración de las ciencias naturales y las ciencias sociales: análisis de un caso relacionado con un problema de salud pública |
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No disponible |
2009 |
El envenenamiento por mordedura de serpiente en Centroamérica |
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No disponible |
2009 |
Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management |
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No disponible |
2009 |
Técnicas de Laboratorio en Inmunología Clínica |
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No disponible |
2009 |
Neutralization of Bothrops asper venom by antibodies, natural products, and synthetic drugs: contributions to understanding snakebite envenomings and their treatment |
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No disponible |
2009 |
Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro |
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No disponible |
2009 |
Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins |
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No disponible |
2009 |
Venom, venomics, antivenomics |
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2009 | |
Experimental pathology of local tissue damage induced by Bothrops asper snake venom |
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No disponible |
2009 |
Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: Report of a workshop |
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No disponible |
2009 |
Biochemistry and toxicology of toxins purified from the venom of the snake Bothrops asper |
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No disponible |
2009 |
Bothrops asper: Beauty and peril in the Neotropics |
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No disponible |
2009 |
Effects of Bothrops asper snake venom on lymphatic vessels: insights into a hidden aspect of envenomation |
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2008 | |
Secretory phospholipases A2 isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases |
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No disponible |
2008 |
Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom |
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No disponible |
2008 |
Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration |
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2008 | |
Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action |
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No disponible |
2008 |
Chemical composition of Schinus molle essential oil and its cytotoxic activity on tumour cell lines |
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2008 | |
Skin Pathology Induced by Snake Venom Metalloproteinase: Acute Damage, Revascularization, and Re-epithelization in a Mouse Ear Model |
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No disponible |
2008 |
Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis |
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No disponible |
2008 |
Snake Venomics and Antivenomics of the Arboreal Neotropical Pitvipers Bothriechis lateralis and Bothriechis schlegelii |
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No disponible |
2008 |
Susceptibilidad de Trypanosoma cruzi a diferentes venenos de serpientes de Costa Rica |
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No disponible |
2008 |
Ability of fucoidan to prevent muscle necrosis induced by snake venom myotoxins: comparison of high- and low-molecular weight fractions |
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2008 | |
Snake Venomics of the Lesser Antillean Pit Vipers Bothrops caribbaeus and Bothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of a Heterologous Antivenom |
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No disponible |
2008 |
Ten simple rules for aspiring scientists in a low-income country |
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No disponible |
2008 |
Systemic and local myotoxicity induced by snake venom group II phospholipases A2: Comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue |
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No disponible |
2008 |
Catalytically inactive phospholipase A2 homologue binds to vascular endothelial growth factor receptor-2 via C-terminal loop region |
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No disponible |
2008 |
Snake Venomics of Central American Pitvipers: Clues for Rationalizing the Distinct Envenomation Profiles of Atropoides nummifer and Atropoides picadoi |
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No disponible |
2008 |
Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper |
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No disponible |
2008 |
Mortality due to snakebite envenomation in Costa Rica (1993–2006) |
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No disponible |
2008 |
Computational Biology in Costa Rica: the role of a small country in the global context of bioinformatics |
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No disponible |
2008 |
Fungicidal activity of a phospholipase A2-derived synthetic peptide variant against Candida albicans |
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No disponible |
2007 |
Strengthening antivenom production in Central and South American public laboratories: Report of a workshop |
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No disponible |
2007 |
Antitumor effects of cationic synthetic peptides derived from Lys49 phospholipase A2 homologues of snake venoms |
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No disponible |
2007 |
Role of cyclooxygenases in oedema-forming activity of bothropic venoms |
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No disponible |
2007 |
Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations |
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No disponible |
2007 |
The snake venom metalloproteinase BaP1 induces joint hypernociception through TNF-α and PGE2-dependent mechanisms |
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No disponible |
2007 |
Structural and functional properties of BaTX, a new Lys49 phospholipase A2 homologue isolated from the venom of the snake Bothrops alternatus |
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No disponible |
2007 |
Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu |
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No disponible |
2007 |
Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations |
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No disponible |
2007 |
Isolation, characterization and molecular cloning of AnMIP, a new α-type phospholipase A2 myotoxin inhibitor from the plasma of the snake Atropoides nummifer (Viperidae: Crotalinae) |
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2007 | |
Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: Evidence of rapid plasma membrane damage and a dual role for extracellular calcium |
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No disponible |
2007 |
Cytotoxicity of Lachesis muta muta snake (bushmaster) venom and its purified basic phospholipase A2 (LmTX-I) in cultured cells |
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No disponible |
2007 |
Increased Infectivity of Staphylococcus aureus in an Experimental Model of Snake Venom–Induced Tissue Damage |
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No disponible |
2007 |
Calcium plays a key role in the effects induced by a snake venom Lys49 phospholipase A2 homologue on a lymphoblastoid cell line |
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No disponible |
2006 |
Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity |
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No disponible |
2006 |
Cytotoxic effect induced by retinoic acid loaded into galactosyl-sphingosine containing liposomes on human hepatoma cell lines |
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No disponible |
2006 |
Effect of calcineurin inhibitors on myotoxic activity of crotoxin and Bothrops asper phospholipase A2 myotoxins in vivo and in vitro |
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No disponible |
2006 |
Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without β-propiolactone, in the treatment of Bothrops asper bites in Colombia |
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No disponible |
2006 |
Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice |
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No disponible |
2006 |
Pharmacokinetics of whole IgG equine antivenom: comparison between normal and envenomed rabbits |
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No disponible |
2006 |
Sexual dimorphism in the second-to-fourth digit length ratio in green anoles, Anolis carolinensis (Squamata: Polychrotidae), from the southeastern United States |
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No disponible |
2006 |
Confronting the neglected problem of snake bite envneoming: the need for a global partnership |
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No disponible |
2006 |
Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines |
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No disponible |
2006 |
Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom |
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No disponible |
2006 |
Biological and structural characterization of crotoxin and new isoform of crotoxin B PLA2 (F6a) from Crotalus durissus collilineatus snake venom |
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No disponible |
2006 |
Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase |
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No disponible |
2006 |
Apoptotic events induced by naturally occurring retinoids ATRA and 13-cis retinoic acid on human hepatoma cell lines Hep3B and HepG2 |
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No disponible |
2005 |
Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle |
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2005 | |
Anticomplementary activity of equine whole IgG antivenoms: comparison of three fractionation protocols |
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2005 | |
Inflammation induced by Bothrops asper venom: release of proinflammatory cytokines and eicosanoids, and role of adhesion molecules in leukocyte infiltration |
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No disponible |
2005 |
Bactericidal and anti-endotoxic properties of short cationic peptides derived from a snake venom Lys49 phospholipase A2 |
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No disponible |
2005 |
Medicinal plants with inhibitory properties against snake venoms |
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No disponible |
2005 |
Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage. |
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No disponible |
2005 |
Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage |
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No disponible |
2005 |
Inhibition of Myotoxic Activity of Bothrops asper Myotoxin II by the Anti-trypanosomal Drug Suramin |
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No disponible |
2005 |
Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa |
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No disponible |
2005 |
Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region |
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2005 | |
La investigación en la Universidad de Costa Rica: situación actual y perspectivas |
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No disponible |
2005 |
Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: In vitro and in vivo gene expression analysis of the effects of the toxin |
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No disponible |
2005 |
Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGs |
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2005 | |
A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C |
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No disponible |
2005 |
A Lys49 phospholipase A2 homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line |
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No disponible |
2005 |
Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity |
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No disponible |
2005 |
Differential susceptibility of C2C12 myoblasts and myotubes to group II phospholipase A2 myotoxins from crotalid snake venoms |
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2005 | |
Activation of cellular functions in macrophages by venom secretory Asp-49 and Lys-49 phospholipases A2 |
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No disponible |
2005 |
Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells |
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2005 | |
Role of TNF-α, IL-1β and IL-6 in the local tissue damage induced by Bothrops asper snake venom: an experimental assessment in mice |
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2005 | |
Effects of neutrophil depletion in the local pathological alterations and muscle regeneration in mice injected with Bothrops jararaca snake venom |
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2005 | |
Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation |
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No disponible |
2005 |
Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment |
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2005 | |
Effect of a recombinant Lys49 PLA2 myotoxin and Lys49 PLA2-derived synthetic peptides from Agkistrodon species on membrane permeability to water. |
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No disponible |
2004 |
Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops atrox |
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2004 | |
Assessment of the viral safety of antivenoms fractionated from equine plasma |
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No disponible |
2004 |
Crystallization of the Lys49 PLA2 homologue, myotoxin II from the venom of Atropoides nummifer |
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No disponible |
2004 |
Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide |
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No disponible |
2004 |
Membrane independent activation of fibroblast proMMP-2 by snake venom: novel roles for venom proteinases |
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No disponible |
2004 |
Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy |
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No disponible |
2004 |
Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA2 from Bothrops asper venom |
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No disponible |
2004 |
Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators |
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No disponible |
2004 |
Feeding behavior and venom toxicity of coral snake Micrurus nigrocinctus (Serpentes: Elapidae) on its natural prey in captivity |
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No disponible |
2004 |
Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom |
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2003 | |
Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venom |
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No disponible |
2003 |
Inhibitory effect of fucoidan on the activities of crotaline snake venom myotoxic phospholipases A2 |
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No disponible |
2003 |
Preclinical assessment of the ability of polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced in Costa Rica to neutralize the venoms of North American snakes |
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2003 | |
Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia |
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2003 | |
Snake venom metalloproteinases: structure/function relationships studies using monoclonal antibodies |
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No disponible |
2003 |
Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity |
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No disponible |
2003 |
A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa |
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No disponible |
2003 |
An overview of Lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action |
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No disponible |
2003 |
Comparative study of synthetic peptides corresponding to region 115-129 in Lys49 myotoxic phospholipases A2 from snake venoms |
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No disponible |
2003 |
Intramuscular administration of antivenoms in experimental envenomation by Bothrops asper: comparison between Fab and IgG |
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2003 | |
Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities |
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No disponible |
2003 |
Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation. |
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No disponible |
2003 |
Efectos locales en el envenenamiento ofídico en América Latina |
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No disponible |
2003 |
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants |
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No disponible |
2003 |
Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis |
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2003 | |
Polyspecific snake antivenom may help in antivenom crisis |
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No disponible |
2003 |
Comprendiendo los venenos de serpientes: 50 años de investigaciones en América Latina |
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No disponible |
2002 |
Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms |
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2002 | |
Hemostatic effects induced by Thalassophryne nattereri fish venom: a model of endothelium-mediated blood flow impairment. |
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No disponible |
2002 |
Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A2 homologue |
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No disponible |
2002 |
Effect of Preservatives on IgG Aggregation, Complement-activating Effect and Hypotensive Activity of Horse Polyvalent Antivenom Used in Snakebite Envenomation |
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2002 | |
Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper |
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No disponible |
2002 |
Functional analysis of DM64, an antimyotoxic protein with immunoglobulin-like structure from Didelphis marsupialis serum |
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No disponible |
2002 |
Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo |
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No disponible |
2001 |
Serum antibody response to polysaccharides in children with recurrent respiratory tract infections |
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No disponible |
2001 |
Peligros de los falsos positivos en la determinación de gonadotropina coriónica |
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No disponible |
2001 |
Dissociation of enzymatic and pharmacological properties of piratoxins-I and -III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom |
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No disponible |
2001 |
Immunochemical properties of the N-terminal helix of myotoxin II, a lysine-49 phospholipase A2 from Bothrops asper snake venom |
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No disponible |
2001 |
Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom |
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No disponible |
2001 |
Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A(2) homologue and neutralization by two antivenoms |
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2001 | |
Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice |
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No disponible |
2001 |
The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms |
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2001 | |
Comparison between IgG and F(ab′)2 polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions |
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2001 | |
Modulation of the Susceptibility of Human Erythrocytes to Snake Venom Myotoxic Phospholipases A2: Role of Negatively Charged Phospholipids as Potential Membrane Binding Sites |
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No disponible |
2001 |
Effects of chemical modifications of crotoxin B, the phospholipase A2 subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities |
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No disponible |
2001 |
Pathological alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom |
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No disponible |
2001 |
Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage |
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2001 | |
Identification of the myotoxic site of the Lys49 phospholipase A2 from Agkistrodon piscivorus piscivorus snake venom: synthetic C-terminal peptides from Lys49, but not from Asp49 myotoxins, exert membrane-damaging activities |
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No disponible |
2001 |
Systemic cytokine response in children bitten by snakes in Costa Rica |
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No disponible |
2001 |
Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper |
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2000 | |
Isolation and characterization of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a new Lys49 phospholipase A2 homologu |
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No disponible |
2000 |
Bothrops asper snake venom and its metalloproteinase BaP–1 activate the complement system. Role in leucocyte recruitment |
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2000 | |
Snake venom metalloproteinases: Their role in the pathogenesis of local tissue damage |
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2000 | |
Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties |
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2000 | |
Structural and functional characterization of BnSP-7, a lysine-49 myotoxic phospholipase A2 homologue from Bothrops neuwiedi pauloensis venom |
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No disponible |
2000 |
Myotoxic phospholipases A2 in Bothrops snake venoms: Effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu |
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No disponible |
2000 |
Structural and functional characterization of myotoxin I, a Lys49 phospholipase A(2) homologue from Bothrops moojeni (Caissaca) snake venom |
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No disponible |
2000 |
Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene |
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2000 | |
Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA |
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2000 | |
Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper |
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2000 | |
Horse IgG isotypes and cross-neutralization of two snake antivenoms produced in Brazil and Costa Rica |
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2000 | |
Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom |
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2000 | |
Desarrollo científico en Costa Rica: un análisis bibliométrico a través del Science Citation Index durante el periodo 1980-1998 |
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No disponible |
2000 |
Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms |
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No disponible |
2000 |
Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica |
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2000 | |
Venom Composition and Diet of the Cantil Agkistrodon bilineatus howardgloydi (Serpentes: Viperidae) |
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No disponible |
1999 |
Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro |
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No disponible |
1999 |
Structure of a Lys49-Phospholipase A2 homologue isolated from the venom of Bothrops nummifer (jumping viper) |
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No disponible |
1999 |
Inhibition of the myotoxic activity of Bothrops aspermyotoxin II in mice by immunization with its synthetic 13-mer peptide 115-129 |
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1999 | |
Bases moleculares del reconocimiento de antígenos |
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No disponible |
1999 |
Instituto Clodomiro Picado: Ciencia y Tecnología Endógenas en la Solución de un Problema de la Salud Pública en Centroamérica |
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No disponible |
1999 |
Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani |
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No disponible |
1999 |
Tyr→Trp-substituted peptide 115-129 of a Lys49 phospholipase A2 expresses enhanced membrane-damaging activities and reproduces its in vivo myotoxic effect |
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No disponible |
1999 |
Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom |
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1999 | |
Envenamiento por mordedura de serpiente en Costa Rica en 1996: Epidemiología y consideraciones clínicas |
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No disponible |
1999 |
A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms |
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1999 | |
Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom |
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1999 | |
Characterization of a basic phospholipase A2-homologue myotoxin isolated from the venom of the snake Bothrops neuwiedii (yarará chica) from Argentina |
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No disponible |
1999 |
Universidad de Costa Rica: liderazgo en producción científica de nivel internacional, 1980-1998. |
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No disponible |
1999 |
Neutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothı́rops snake venoms |
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No disponible |
1999 |
Elapid venom toxins: multiple recruitments of ancient scaffolds |
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No disponible |
1999 |
Inhibition by CaNa2EDTA of local tissue damage induced by Bothrops asper (terciopelo) venom: Application in horse immunization for antivenom production |
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1998 | |
Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom |
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1998 | |
Amino acid sequence of a myotoxic Lys49-phospholipase A2 homologue from the venom of Cerrophidion (Bothrops) godmani |
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1998 | |
Comparative study of the venoms of three subspecies of Lachesis muta (bushmaster) from Brazil, Colombia and Costa Rica |
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No disponible |
1998 |
Bactericidal activity of Lys49 and Asp49 myotoxic phospholipases A2 from Bothrops asper snake venom: synthetic Lys49 myotoxin II-(115-129)-peptide identifies its bactericidal region |
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No disponible |
1998 |
Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper |
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1998 | |
Immunochemical characterization and role in toxic activities of region 115-129 of myotoxin II, a Lys49 phospholipase A2 from Bothrops asper snake venom |
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1998 | |
Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo) |
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1998 | |
Biochemical characterization and pharmacological properties of a phospholipase A2 myotoxin inhibitor from the plasma of the snake Bothrops asper |
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1997 | |
Development of immunoassays for determination of circulating venom antigens during envenomations by coral snakes (Micrurus species) |
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No disponible |
1997 |
A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus |
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No disponible |
1997 |
Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom |
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No disponible |
1997 |
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: Comparison with two commercial antivenoms |
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No disponible |
1997 |
Immunoglobulin G and F(ab')2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom |
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No disponible |
1997 |
Lys-49 phospholipases A2 as active enzymes for beta-arachidonoyl phospholipid bilayer membranes |
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No disponible |
1997 |
Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: effects on enzymatic and pharmacological properties |
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No disponible |
1997 |
Inhibition of toxic activities of Bothrops asper venom and other crotalid snake venoms by a novel neutralizing mixture |
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No disponible |
1997 |
Inhibition of the hemorrhagic activity of Bothrops asper venom by a novel neutralizing mixture |
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No disponible |
1997 |
Isolation and characterization of a myotoxic phospholipase A2 from the venom of the arboreal snake Bothriechis (Bothrops) schlegelii from Costa Rica |
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No disponible |
1997 |
Snakebite mortality in Costa Rica |
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1997 | |
A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia |
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No disponible |
1996 |
Biochemical and biological characterization of Ecuadorian pitviper venoms (genera Bothriechis, Bothriopsis, Bothrops and Lachesis) |
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No disponible |
1996 |
Effect of adjuvants on the antibody response of mice to Bothrops asper (Terciopelo) snake venom |
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No disponible |
1996 |
Characterization of alpha-neurotoxin and phospholipase A2 activities from Micrurus venoms. Determination of the amino acid sequence and receptor-binding ability of the major alpha-neurotoxin from Micrurus nigrocinctus nigrocinctus |
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No disponible |
1996 |
Las citokinas, elementos centrales para la comprensión y manipulación terapéutica del sistema inmune (Parte II) |
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No disponible |
1996 |
Evaluation of the neutralizing ability of antivenoms for the treatment of snake bite envenoming in Central America |
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No disponible |
1996 |
Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice |
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No disponible |
1996 |
Antibody-mediated neutralization and binding-reversal studies on α-neurotoxins from micrurus nigrocinctus nigrocinctus (coral snake) venom |
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No disponible |
1996 |
Similar effectiveness of Fab and F(ab')2 antivenoms in the neutralization of hemorrhagic activity of Vipera berus snake venom in mice |
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No disponible |
1996 |
Phospholipase A2 myotoxins from Bothrops snake venoms |
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No disponible |
1995 |
Phospholipase A2 and inflammation |
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No disponible |
1995 |
Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo) |
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No disponible |
1995 |
Evaluación de la capacidad de cuatro antivenenos comerciales para neutralizar el veneno de la serpiente Bothrops asper (terciopelo) de Costa Rica |
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No disponible |
1995 |
Immunological studies on BaH1 and BaPI, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper |
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No disponible |
1995 |
Purification and characterization of myotoxin IV, a phospholipase A2 variant, from Bothrops asper snake venom |
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No disponible |
1995 |
In vitro activity of BaH1, the main hemorrhagic toxin of Bothrops asper snake venom on bovine endothelial cells |
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No disponible |
1995 |
Autocatalytic acylation of phospholipase-like myotoxins |
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No disponible |
1995 |
Acute-phase reactions, including cytokines, in patients bitten by Bothrops and Crotalus snakes in Brazil |
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No disponible |
1995 |
Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice |
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No disponible |
1995 |
Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom |
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No disponible |
1995 |
Ability of six Latin American antivenoms to neutralize the venom of mapaná equis (Bothrops atrox) from Antioquia and Chocó (Colombia) |
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No disponible |
1995 |
The ability of specific antivenom and low temperature to inhibit the myotoxicity and neuromuscular block induced by Micrurus nigrocinctus venom |
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No disponible |
1995 |
Las citokinas, elementos centrales para la comprensión y manipulación terapéutica del sistema inmune (Parte 1) |
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|
No disponible |
1995 |
Phospholipase A2 myotoxins from Bothrops snake venoms [Artículo de revisión] |
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No disponible |
1995 |
Structure of a calcium-independent phospholipase-like myotoxic protein from Bothrops asper venom |
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No disponible |
1995 |
Skeletal Muscle Necrosis and Regeneration after Injection of BaH1, A Hemorrhagic Metalloproteinase Isolated from the Venom of the Snake Bothrops asper (Terciopelo) |
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No disponible |
1995 |
Broad cytolytic specificity of myotoxin II, a lysine-49 phospholipase A2 of Bothrops asper snake venom |
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No disponible |
1994 |
Effect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitro |
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No disponible |
1994 |
A potent antihemorrhagin in the serum of the non-poisonous water snake Natrix tessellata: isolation, characterization and mechanism of neutralization |
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No disponible |
1994 |
Caprylic acid fractionation of hyperimmune horse plasma: description of a simple procedure for antivenom production |
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No disponible |
1994 |
The dynamics of local tissue damage induced by Bothrops asper snake venom and myotoxin II on the mouse cremaster muscle: an intravital and electron microscopic study |
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No disponible |
1994 |
Neutralizing interaction between heparins and myotoxin II, a Lys-49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling |
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No disponible |
1994 |
Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect |
|
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No disponible |
1994 |
Pathological changes induced by BaH1, a hemorrhagic proteinase isolated from Bothrops asper (Terciopelo) snake venom, on mouse capillary blood vessels |
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No disponible |
1994 |
Immunochemical characterization of Micrurus nigrocinctus nigrocinctus venom with monoclonal and polyclonal antibodies |
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|
No disponible |
1994 |
Electrophoretic and immunochemical studies of Micrurus venoms |
|
|
No disponible |
1994 |
Activity of hemorrhagic metalloproteinase BaH-1 and myotoxin II from Bothrops asper snake venom on capillary endothelial cells in vitro |
|
|
No disponible |
1994 |
Neutralization of the cytolytic and myotoxic activities of phospholipases A2 from Bothrops asper snake venom by glycosaminoglycans of the heparin/heparan sulfate family |
|
|
No disponible |
1994 |
Crystallization and preliminary diffraction data of two myotoxins isolated from the venoms of Bothrops asper (Terciopelo) and Bothrops nummifer (jumping viper) |
|
|
No disponible |
1993 |
Effects on cultured mammalian cells of myotoxin III, a phospholipase A2 isolated from Bothrops asper (terciopelo) venom |
|
|
No disponible |
1993 |
Effects of Bothrops asper (terciopelo) myotoxin III, a basic phospholipase A2, on liposomes and mouse gastrocnemius muscle |
|
|
No disponible |
1993 |
Biological and biochemical activities of Vipera berus (European viper) venom |
|
|
No disponible |
1993 |
Comparison of the immunogenicity and antigenic composition of ten Central American snake venoms |
|
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No disponible |
1993 |
Host response to Bothrops asper snake venom: analysis of edema formation, inflammatory cells, and cytokine release in a mouse model |
|
|
No disponible |
1993 |
Isolation and characterization of synergistic hemorrhagins from the venom of the snake Bothrops asper |
|
|
No disponible |
1993 |
Turbidity of hyperimmune equine antivenom: the role of phenol and serum lipoproteins |
|
|
No disponible |
1993 |
An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies |
|
|
No disponible |
1993 |
p-Bromophenacyl bromide modification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2, affects its pharmacological activities |
|
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No disponible |
1993 |
A eficácia do antiveneno botrópico-crotálico na neutralização das principais atividades do veneno de Bothrops jararacussu |
|
|
No disponible |
1992 |
An electrophoretic study on phospholipase A2 isoenzymes in the venoms of Central American crotaline snakes |
|
|
No disponible |
1992 |
Immunoenzymatic quantitation of antibodies to Bothrops asper myotoxins after polyvalent antivenom administration in mice. |
|
|
No disponible |
1992 |
Effect of Bothrops asper (Fer-De-Lance) snake venom on erythrocyte membrane. A comparative study |
|
|
No disponible |
1992 |
Experimental myonecrosis induced by the venoms of South American Micrurus (coral snakes) |
|
|
No disponible |
1992 |
Pathological and biochemical changes induced in mice after intramuscular injection of venom from newborn specimens of the snake Bothrops asper (Terciopelo) |
|
|
No disponible |
1992 |
Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies |
|
|
No disponible |
1992 |
Calcium ion independent membrane leakage induced by phospholipase-like myotoxins |
|
|
No disponible |
1992 |
Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (Terciopelo) |
|
|
No disponible |
1992 |
Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman's pit viper) snake venom |
|
|
No disponible |
1992 |
Individual expression patterns of myotoxin isoforms in the venom of the snake Bothrops Asper. |
|
|
No disponible |
1992 |
DNase activity in Costa Rican crotaline snake venoms: quantification of activity and identification of electrophoretic variants. |
|
|
No disponible |
1991 |
Myotoxin II from Bothrops asper (Terciopelo) venom is a lysine-49 phospholipase A2 |
|
|
No disponible |
1991 |
Biochemical and pharmacological similarities between the venoms of newborn Crotalus durissus durissus and adult Crotalus durissus terrificus rattlesnakes |
|
|
No disponible |
1991 |
Skeletal muscle degeneration and regeneration after injection of bothropstoxin-II, a phospholipase A2 isolated from the venom of the snake Bothrops jararacussu |
|
|
No disponible |
1991 |
The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities |
|
|
No disponible |
1991 |
Degenerative and regenerative changes in murine skeletal muscle after injection of venom from the snake Bothrops asper: a histochemical and immunocytochemical study. |
|
|
No disponible |
1991 |
Neutralization of coral snake Micrurus nigrocinctus venom by a monovalent antivenom |
|
|
No disponible |
1991 |
Quantitation by enzyme-immunoassay of antibodies against Bothrops myotoxins in four commercially-available antivenoms |
|
|
No disponible |
1991 |
Effect of storage temperature on the stability of polyvalent antivenom produced in Costa Rica. |
|
|
No disponible |
1990 |
The amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asper |
|
|
No disponible |
1990 |
Equine antibodies to Bothrops asper myotoxin II: isolation from polyvalent antivenom and neutralizing ability. |
|
|
No disponible |
1990 |
South American snake venom proteins antigenically-related to Bothrops asper myotoxins. |
|
|
No disponible |
1990 |
Isolation of a galactose-binding lectin from the venom of the snake Bothrops godmani (Godmann's pit viper). |
|
|
No disponible |
1990 |
Standardization of assays for testing the neutralizing ability of antivenoms |
|
|
No disponible |
1990 |
Isolation of basic myotoxins from Bothrops Moojeni and Bothrops Atrox snake venoms |
|
|
No disponible |
1990 |
Dissociation of enzymatic and toxic activities by the use of antibodies |
|
|
No disponible |
1990 |
Ontogenetic changes in the venom of the snake Lachesis muta stenophrys (bushmaster) from Costa Rica |
|
|
No disponible |
1990 |
Histopathological and biochemical alterations induced by intramuscular injection of Bothrops asper (terciopelo) venom in mice |
|
|
No disponible |
1989 |
Desarrollo de la respuesta de anticuerpos anti-fosfolipasa A, en caballos inoculados con veneno para la producción de suero antiofídico polivalente en Costa Rica |
|
|
No disponible |
1989 |
Local tissue damage induced by Bothrops snake venoms - A review |
|
|
No disponible |
1989 |
A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo) |
|
|
No disponible |
1989 |
Efecto del suero antiofídico sobre la actividad hemolítica del complemento humano (in vitro) y de conejo (in vitro e in vivo). |
|
|
No disponible |
1989 |
Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica |
|
|
No disponible |
1989 |
Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom |
|
|
No disponible |
1989 |
El suero de neonatos de Clelia clelia (Serpentes: Colubridae) neutraliza la acción hemorrágica del veneno de Bothrops asper (Serpentes: Viperidae). |
|
|
No disponible |
1989 |
Production and partial characterization of monoclonal antibodies to Bothrops asper (terciopelo) myotoxin |
|
|
No disponible |
1988 |
El suero antiofídico polivalente producido en Costa Rica: Estabilidad y capacidad neutralizante |
|
|
No disponible |
1988 |
Body distribution of Bothrops asper (terciopelo) snake venom myotoxin and its relationship to pathological changes |
|
|
No disponible |
1988 |
A new method for the detection of phospholipase A2 variants: identification of isozymes in the venoms of newborn and adult Bothrops asper (terciopelo) snakes |
|
|
No disponible |
1988 |
Karyotypes of five species of coral snakes (Micrurus) |
|
|
No disponible |
1988 |
An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica |
|
|
No disponible |
1988 |
Skeletal muscle necrosis induced by a phospholipase A2 isolated from the venom of the coral snake Micrurus nigrocinctus nigrocinctus. |
|
|
No disponible |
1987 |
Immunohistochemical demonstration of the binding of bothrops asper myotoxin to skeletal muscle sarcolemma |
|
|
No disponible |
1987 |
Neutralización de las actividades tóxicas y enzimáticas de cuatro venenos de serpientes de Guatemala y Honduras por el antiveneno polivalente producido en Costa Rica |
|
|
No disponible |
1987 |
Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo) |
|
|
No disponible |
1987 |
Ability of a polyvalent antivenom to neutralize the venom of Lachesis muta melanocephala, a new Costa Rican subspecies of the bushmaster |
|
|
No disponible |
1987 |
Effects of a myotoxic phospholipase A2 isolated from Bothrops asper venom on skeletal muscle sarcoplasmic reticulum |
|
|
No disponible |
1987 |
Detection of proteins antigenically-related to Bothrops asper myotoxin in crotaline snake venoms |
|
|
No disponible |
1987 |
Comparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenom |
|
|
No disponible |
1986 |
Pharmacological activities of a toxic phospholipase A isolated from the venom of the snake Bothrops asper |
|
|
No disponible |
1986 |
Inflammatory infiltrate in skeletal muscle injected with Bothrops asper venom |
|
|
No disponible |
1986 |
Determinación cuantitativa de la actividad lítica del complemento sérico (CH50) en adultos costarricenses |
|
|
No disponible |
1986 |
Pathogenesis of myonecrosis induced by coral snake (Micrurus nigrocinctus) venom in mice |
|
|
No disponible |
1986 |
Isolation and partial characterization of a myotoxin from the venom of the snake Bothrops nummifer |
|
|
No disponible |
1986 |
Cálculo de la actividad hemolítica del complemento sérico (CH50) mediante un programa en "BASIC": Comparación con el método gráfico manual. |
|
|
No disponible |
1986 |
Algunas reflexiones sobre Clodomiro Picado Twight y su contribución al desarrollo de las ciencias médicas y naturales de Costa Rica |
|
|
No disponible |
1986 |
Porcentaje y cifra absoluta de linfocitos T en sangre periférica por el método de rosetas E: estudio de cuarenta adultos sanos |
|
|
No disponible |
1985 |
Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom |
|
|
No disponible |
1985 |
Producción de placas de inmunodifusión radial para la cuantificación de IgG humana |
|
|
No disponible |
1985 |
Isolation from a polyvalent antivenom of antibodies to a myotoxin in Bothrops asper snake venom |
|
|
1985 | |
Niveles de inmunoglobulinas séricas (IgG, IgA e IgM) en adultos jóvenes sanos, por el método de inmunodifusión radial |
|
|
No disponible |
1985 |
Edema-forming activity of bushmaster (Lachesis muta stenophrys) and Central American rattlesnake (Crotalus durissus durissus) venoms and neutralization by a polyvalent antivenom |
|
|
No disponible |
1985 |
Cambios en el patrón electroforético del veneno de cascabela muda (Lachesis muta stenophrys) durante el almacenamiento bajo diferentes condiciones |
|
|
No disponible |
1985 |
Estudios cariológicos de cinco especies de serpientes costarricenses de la familia colubridae |
|
|
No disponible |
1984 |
Skeletal muscle regeneration after myonecrosis induced by crude venom and a myotoxin from the snake Bothrops asper (Fer-de-Lance). |
|
|
No disponible |
1984 |
Mecanismo de acción de miotoxinas aisladas de venenos de serpientes |
|
|
No disponible |
1984 |
Isolation of a myotoxin from Bothrops asper venom: Partial characterization and action on skeletal muscle |
|
|
No disponible |
1984 |
Pathogenesis of myonecrosis induced by crude venom and a myotoxin of Bothrops asper. |
|
|
No disponible |
1984 |
Estudio comparativo de los venenos de serpiente Cascabel (Crotalus durissus durissus) de ejemplares adultos y recien nacidos |
|
|
No disponible |
1983 |
Local effects induced by coral snake venoms: Evidence of myonecrosis after experimental inoculations of venoms from five species |
|
|
No disponible |
1983 |
La actividad proteolítica de los venenos de serpientes de Costa Rica sobre la caseína |
|
|
No disponible |
1983 |
Patogénesis y neutralización de los efectos locales inducidos por el veneno de la serpiente "terciopelo" (Bothrops asper). |
|
|
No disponible |
1982 |
Estudio de la capacidad ofiófaga y la resistencia de la zopilota (Clelia clelia, Colubridae) de Costa Rica a los venenos de serpiente |
|
|
No disponible |
1982 |
Neutralization of local effects of the terciopelo (Bothrops asper) venom by blood serum of the colubrid snake Clelia clelia |
|
|
No disponible |
1982 |
Quantitation of myonecrosis induced by myotoxin a from prairie rattlesnake (Crotalus viridis viridis) venom |
|
|
No disponible |
1982 |
Anemias hemolíticas por autoinmunidad y por mecanismos inmunes inducidos por medicamentos |
|
|
No disponible |
1981 |
Polimorfismo cromosómico intraespecífico en la serpiente de coral Micrurus nigrocinctus (Ophidia: Elapidae) |
|
|
No disponible |
1981 |
Estudio comparativo de venenos de ejemplares recien nacidos y adultos de Bothrops asper |
|
|
No disponible |
1980 |
El problema de los efectos hemorrágico y mionecrótico por mordeduras de serpiente en el continente Americano |
|
|
No disponible |
1980 |
Efectos proteolitico, hemorragico y mionecrotico de los venenos de serpientes costarricenses de los generos Bothrops, Crotalus y Lachesis |
|
|
No disponible |
1980 |
Karyotype of the yellow-bellied sea snake, Pelamis platurus |
|
|
No disponible |
1980 |
Mionecrosis, hemorragia y edema inducidos por el veneno de Bothrops asper en ratón blanco |
|
|
No disponible |
1980 |
Cariotipos de diez especies de serpientes costarricenses de la familia Viperidae |
|
|
No disponible |
1979 |
Cariotipos de las principales serpientes coral (Elapidae: Micrurus) de Costa Rica |
|
|
No disponible |
1979 |
CÓDIGO PROYECTO | NOMBRE PROYECTO | INFORME | FECHA DE ENTREGA |
|
ENLACE | |
---|---|---|---|---|---|---|
B9523-22 | DEVELANDO LOS MECANISMOS DE DESARROLLO TRANSCRIPCIÓN DE LA SÍNTESIS TEMPRANA DE LOS BUFADIENÓLIDOS CITOTÓXICOS, ANTIMICROBIANOS Y CARDIOTÓNICOS EN SAPOS | 2 | 31/03/2024 | Devuelto con observaciones | Ver informe | Ver evaluación / Agregar acta |
C1653 | INTEGRATING THE BEHAVIOURAL AND CHEMICAL ECOLOGY OF ANTIPREDATOR DEFENCES IN COSTA RICAN POISON FROGS | 3 | 31/12/2023 | Recibido con observaciones | Ver informe | Ver evaluación / Agregar acta |