Investigador(a)

Guillermo Leon Montero

  • Correo electrónico: GUILLERMO.LEON@ucr.ac.cr
  • Categoría Regimen Académico: PROF. INTERINO LIC.
  • Grado Académico: Ph.D.
  • Unidad Base: INSTITUTO CLODOMIRO PICADO

Distinciones

Distinción Año Entidad Ámbito Descripción
OTRA DISTINCION 2009 Ministerio De Ciencia, Tecnologia Y Telecomunicaciones NACIONAL PREMIO NACIONAL DE TECNOLOGIA

BECAS

País Entidad Año de inicio Año de término Descripción
No hay datos disponibles

Publicaciones

Mostrando 69 publicaciones

TÍTULO TIPO FECHA PROYECTO
In vitro Characterization of Anti-SARS-CoV-2 Intravenous Immunoglobulins (IVIg) Produced From Plasma of Donors Immunized With the BNT162b2 Vaccine and Its Comparison With a Similar Formulation Produced From Plasma of COVID-19 Convalescent Donors
  • artículo original
2022
Assessing a 6-h endpoint observation time in the lethality neutralization assay used to evaluate the preclinical efficacy of snake antivenoms
  • artículo original
2021
Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19
  • artículo original
2021
Physical characteristics of nano-Hydroxyapatite Pickering-emulsions and their adjuvant activity on the antibody response towards the Bothros asper snake venom
  • artículo original
2019

No disponible

Effect of exposition to chlorpyrifos upon plasmatic cholinesterases, hematology and blood biochemistry values in Bothrops asper (Serpentes: Viperidae)
  • artículo original
2018
Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus
  • artículo original
2018
Comparison of the adjuvant activity of emulsions with different physicochemical properties on the antibody response towards the venom of West African carpet viper (Echis ocellatus)
  • artículo original
2017
Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead
  • artículo original
2017

No disponible

Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab0)2 and whole IgG antivenoms
  • artículo original
2016

No disponible

Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom
  • artículo original
2016

No disponible

Assessing endotoxins in equine-derived snake antivenoms: Comparison of the USP pyrogen test and the Limulus Amoebocyte Lysate assay (LAL)
  • artículo original
2015
Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step
  • artículo original
2015
Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom
  • artículo original
2015
Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica
  • artículo original
2014

No disponible

Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: Comparison of their stability in an accelerated test
  • artículo original
2014

No disponible

Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom
  • artículo original
2014

No disponible

Industrial Production and Quality Control of Snake Antivenoms
  • capítulo de libro
2014

No disponible

Antivenomic Characterization of Two Antivenoms Against the Venom of the Taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia
  • artículo original
2014

No disponible

Epidemiology of rapes in Costa Rica: Characterization of victims, perpetrators and circumstances surrounding forced intercourse
  • artículo original
2014

No disponible

Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms
  • artículo original
2013

No disponible

Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics
  • artículo original
2013

No disponible

Role of the animal model on the pharmacokinetics of equine-derived antivenoms
  • artículo original
2013

No disponible

Venom of Bothrops asper from Mexico and Costa Rica: Intraspecific variation and cross-neutralization by antivenoms
  • artículo original
2012
La situación de los antivenenos liofilizados en América Latina: Aspectos tecnológicos y de salud pública
  • artículo original
2012

No disponible

Low pH formulation of whole IgG antivenom: Impact on quality, safety, neutralizing potency and viral inactivation
  • artículo original
2012

No disponible

Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab0)2] antivenoms, in Bothrops asper bites in Colombia
  • artículo original
2012

No disponible

Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: Keys to understand the variable immune response in horses
  • artículo original
2012

No disponible

Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: Role of neurotoxic and procoagulant effects in venom toxicity
  • artículo original
2012

No disponible

Purification of IgG and albumin from human plasma by aqueous two phase system fractionation
  • artículo original
2012

No disponible

Antivenoms for the treatment of snakebite envenomings: The road ahead
  • artículo original
2011

No disponible

Immune Response Towards Snake Venoms
  • artículo original
2011
Antivenoms for Snakebite Envenomings
  • artículo original
2011

No disponible

Método para la producción de formulaciones inyectables de productos proteicos hemoderivados y productos obtenidos utilizando dicho método
  • patente
2011
Preclinical evaluation of caprylic-acid fractionated IgG antivenom for the treatment of taipan (Oxyuranus scutellatus) envneoming in Papua New Guinea
  • artículo original
2011

No disponible

Snake Venomics of African Spitting Cobras: Toxin Composition and Assessment of Congeneric Cross-Reactivity of the Pan-African EchiTAb-Plus-ICP Antivenom by Antivenomics and Neutralization Approaches
  • artículo original
2011
Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenoms
  • artículo original
2011
Neutralization of Bothrops mattogrossensis snake venom from Bolivia: Experimental evaluation of llama and donkey antivenoms produced by caprylic acid precipitation
  • artículo original
2010

No disponible

Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms
  • artículo original
2010

No disponible

Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom
  • artículo original
2010

No disponible

Antivenomic Assessment of the Immunological Reactivity of EchiTAb-Plus-ICP, an Antivenom for the Treatment of Snakebite Envenoming in Sub-Saharan Africa
  • artículo original
2010

No disponible

Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows
  • artículo original
2010

No disponible

Impact of Regional Variation in Bothrops asper Snake Venom on the Design of Antivenoms: Integrating Antivenomics and Neutralization Approaches
  • artículo original
2010

No disponible

Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa
  • artículo original
2010

No disponible

Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming
  • artículo original
2009

No disponible

Neutralization of Bothrops asper venom by antibodies, natural products, and synthetic drugs: contributions to understanding snakebite envenomings and their treatment
  • artículo original
2009

No disponible

Stability of equine IgG antivenoms obtained by caprylic acid precipitation: Towards a liquid formulation stable at tropical room temperature
  • artículo original
2009

No disponible

Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration
  • artículo original
2008
Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations
  • artículo original
2007

No disponible

Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations
  • artículo original
2007

No disponible

Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without β-propiolactone, in the treatment of Bothrops asper bites in Colombia
  • artículo original
2006

No disponible

Anticomplementary activity of equine whole IgG antivenoms: comparison of three fractionation protocols
  • artículo original
2005
Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGs
  • artículo original
2005
Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa
  • artículo original
2005

No disponible

Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation.
  • artículo original
2003

No disponible

Effect of Preservatives on IgG Aggregation, Complement-activating Effect and Hypotensive Activity of Horse Polyvalent Antivenom Used in Snakebite Envenomation
  • artículo original
2002
Modulation of the Susceptibility of Human Erythrocytes to Snake Venom Myotoxic Phospholipases A2: Role of Negatively Charged Phospholipids as Potential Membrane Binding Sites
  • artículo original
2001

No disponible

Comparison between IgG and F(ab′)2 polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions
  • artículo original
2001
Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA
  • artículo original
2000
Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom
  • artículo original
2000
Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom
  • artículo original
1999
A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms
  • artículo original
1999
Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom
  • artículo original
1998
Inhibition by CaNa2EDTA of local tissue damage induced by Bothrops asper (terciopelo) venom: Application in horse immunization for antivenom production
  • artículo original
1998
Immunoglobulin G and F(ab')2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom
  • artículo original
1997

No disponible

Similar effectiveness of Fab and F(ab')2 antivenoms in the neutralization of hemorrhagic activity of Vipera berus snake venom in mice
  • artículo original
1996

No disponible