Alexandra Rucavado Romero

Investigador(a)

Correo electrónico: ALEXANDRA.RUCAVADO@ucr.ac.cr

Categoría Regimen Académico: CATEDRATICO
Grado Académico: DRA.
Unidad Base: FACULTAD DE MICROBIOLOGÍA

Proyectos
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Publicaciones

Mostrando 69 publicaciones

TÍTULO	TIPO	FECHA	PROYECTO
Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms	artículo original	2018	No disponible
Comparison of biochemical and cytotoxic activities of extracts obtained from dorsal spines and caudal fin of adult and juvenile non-native Caribbean lionfish (Pterois volitans/miles)	artículo original	2017	B3011
Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis	artículo original	2016	No disponible
Metaloproteinasas dependientes de Zinc: Protagonistas centrales en la Fisiopatología de Envenenamientos por Serpientes de la familia Viperidae	capítulo de libro	2016	No disponible
Novel catalytically-inactive PII metalloproteinases from a viperid snake venom with substitutions in the canonical zinc-binding motif	artículo original	2016	B2517 B0528
Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities	artículo original	2016	B1654 B5108
Hemorrhage Caused by Snake Venom Metalloproteinases: A Journey of Discovery and Understanding	artículo original	2016	No disponible
Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage	artículo original	2015	No disponible
Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: Insights from a Model with Extract Administration before Venom Injection	artículo original	2015	No disponible
The lethality test used for estimating the potency of antivenoms against Bothrops asper snake venom: Pathophysiological mechanisms, prophylactic analgesia, and a surrogate in vitro assay	artículo original	2015	B2652
Understanding structural and functional aspects of PII snake venom metalloproteinases: Characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis	artículo original	2014	No disponible
A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom	artículo original	2014	No disponible
Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus	artículo original	2014	No disponible
Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom	artículo original	2014	B3760
Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation	artículo original	2014	A2036 A1504
Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture	artículo original	2013	No disponible
Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase	artículo original	2013	No disponible
Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model	artículo original	2013	No disponible
Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico	artículo original	2013	No disponible
Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom	artículo original	2013	No disponible
Identification of New Snake Venom Metalloproteinase Inhibitors Using Compound Screening and Rational Peptide Design	artículo original	2012	No disponible
Efficacy of IgG and F(ab′)2 Antivenoms to Neutralize Snake Venom-induced Local Tissue Damage as Assessed by the Proteomic Analysis of Wound Exudate	artículo original	2012	A9003 B0528
Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom	artículo original	2012	No disponible
Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases	artículo original	2011	No disponible
Poor regenerative outcome after skeletal muscle necrosis induced by Bothrops asper venom: alterations in microvasculature and nerves	artículo original	2011	A7604
Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases	artículo original	2011	A7604 A7502 B0606
Venenos de serpientes de la familia Viperidae en América: Bioquímica y fisiopatología.	capítulo de libro	2011	No disponible
Proteomics of Wound Exudate in Snake Venom-Induced Pathology: Search for Biomarkers To Assess Tissue Damage and Therapeutic Success	artículo original	2011	No disponible
Immunochemical and biological characterization of monoclonal antibodies against BaP1, a metalloproteinase from Bothrops asper snake venom	artículo original	2010	No disponible
Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?	artículo original	2010	No disponible
Experimental pathology of local tissue damage induced by Bothrops asper snake venom	artículo original	2009	No disponible
Neutralization of Bothrops asper venom by antibodies, natural products, and synthetic drugs: contributions to understanding snakebite envenomings and their treatment	artículo original	2009	No disponible
Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins	artículo original	2009	No disponible
Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom	artículo original	2009	No disponible
Skin Pathology Induced by Snake Venom Metalloproteinase: Acute Damage, Revascularization, and Re-epithelization in a Mouse Ear Model	artículo original	2008	No disponible
Snake Venomics of the Lesser Antillean Pit Vipers Bothrops caribbaeus and Bothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of a Heterologous Antivenom	artículo original	2008	No disponible
Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper	artículo original	2008	No disponible
Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom	artículo original	2008	No disponible
Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations	artículo original	2007	No disponible
Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations	artículo original	2007	No disponible
Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu	artículo original	2007	No disponible
Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase	artículo original	2006	No disponible
Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines	artículo original	2006	No disponible
Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage.	artículo original	2005	No disponible
Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage	artículo original	2005	No disponible
Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells	artículo original	2005	A0049
Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy	artículo original	2004	No disponible
Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom	artículo original	2003	A1504 A2036
Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities	artículo original	2003	No disponible
Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis	artículo original	2003	A1504 A2036
Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper	artículo original	2002	No disponible
Modulation of the Susceptibility of Human Erythrocytes to Snake Venom Myotoxic Phospholipases A2: Role of Negatively Charged Phospholipids as Potential Membrane Binding Sites	artículo original	2001	No disponible
Pathological alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom	artículo original	2001	No disponible
Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice	artículo original	2001	No disponible
Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage	artículo original	2001	98505
Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper	artículo original	2000	98202
Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA	artículo original	2000	98202
Snake venom metalloproteinases: Their role in the pathogenesis of local tissue damage	artículo original	2000	98202
Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene	artículo original	2000	98287
Bothrops asper snake venom and its metalloproteinase BaP–1 activate the complement system. Role in leucocyte recruitment	artículo original	2000	98202
Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper	artículo original	2000	98202
Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom	artículo original	1999	98202
Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom	artículo original	1998	89057
Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper	artículo original	1998	96262
Isolation and characterization of a myotoxic phospholipase A2 from the venom of the arboreal snake Bothriechis (Bothrops) schlegelii from Costa Rica	artículo original	1997	No disponible
Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice	artículo original	1996	No disponible
Effect of adjuvants on the antibody response of mice to Bothrops asper (Terciopelo) snake venom	artículo original	1996	No disponible
Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom	artículo original	1995	No disponible
Immunological studies on BaH1 and BaPI, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper	artículo original	1995	No disponible