Investigador(a)

Alexandra Rucavado Romero

  • Correo electrónico: ALEXANDRA.RUCAVADO@ucr.ac.cr
  • Categoría Regimen Académico: CATEDRATICO
  • Grado Académico: DR.
  • Unidad Base: FACULTAD DE MICROBIOLOGÍA

Distinciones

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BECAS

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Publicaciones

Mostrando 69 publicaciones

TÍTULO TIPO FECHA PROYECTO
Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms
  • artículo científico
2018

No disponible

Comparison of biochemical and cytotoxic activities of extracts obtained from dorsal spines and caudal fin of adult and juvenile non-native Caribbean lionfish (Pterois volitans/miles)
  • artículo científico
2017
Novel catalytically-inactive PII metalloproteinases from a viperid snake venom with substitutions in the canonical zinc-binding motif
  • artículo científico
2016
Metaloproteinasas dependientes de Zinc: Protagonistas centrales en la Fisiopatología de Envenenamientos por Serpientes de la familia Viperidae
  • capítulo de libro
2016

No disponible

Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis
  • artículo científico
2016

No disponible

Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities
  • artículo científico
2016
Hemorrhage Caused by Snake Venom Metalloproteinases: A Journey of Discovery and Understanding
  • artículo científico
2016

No disponible

Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: Insights from a Model with Extract Administration before Venom Injection
  • artículo científico
2015

No disponible

Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage
  • artículo científico
2015

No disponible

The lethality test used for estimating the potency of antivenoms against Bothrops asper snake venom: Pathophysiological mechanisms, prophylactic analgesia, and a surrogate in vitro assay
  • artículo científico
2015
Understanding structural and functional aspects of PII snake venom metalloproteinases: Characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis
  • artículo científico
2014

No disponible

Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation
  • artículo científico
2014
Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus
  • artículo científico
2014

No disponible

A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom
  • artículo científico
2014

No disponible

Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom
  • artículo científico
2014
Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico
  • artículo científico
2013

No disponible

Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model
  • artículo científico
2013

No disponible

Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase
  • artículo científico
2013

No disponible

Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture
  • artículo científico
2013

No disponible

Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom
  • artículo científico
2013

No disponible

Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom
  • artículo científico
2012

No disponible

Identification of New Snake Venom Metalloproteinase Inhibitors Using Compound Screening and Rational Peptide Design
  • artículo científico
2012

No disponible

Efficacy of IgG and F(ab′)2 Antivenoms to Neutralize Snake Venom-induced Local Tissue Damage as Assessed by the Proteomic Analysis of Wound Exudate
  • artículo científico
2012
Poor regenerative outcome after skeletal muscle necrosis induced by Bothrops asper venom: alterations in microvasculature and nerves
  • artículo científico
2011
Venenos de serpientes de la familia Viperidae en América: Bioquímica y fisiopatología.
  • capítulo de libro
2011

No disponible

Proteomics of Wound Exudate in Snake Venom-Induced Pathology: Search for Biomarkers To Assess Tissue Damage and Therapeutic Success
  • artículo científico
2011

No disponible

Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases
  • artículo científico
2011

No disponible

Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases
  • artículo científico
2011
Immunochemical and biological characterization of monoclonal antibodies against BaP1, a metalloproteinase from Bothrops asper snake venom
  • artículo científico
2010

No disponible

Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?
  • artículo científico
2010

No disponible

Experimental pathology of local tissue damage induced by Bothrops asper snake venom
  • artículo científico
2009

No disponible

Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom
  • artículo científico
2009

No disponible

Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins
  • artículo científico
2009

No disponible

Neutralization of Bothrops asper venom by antibodies, natural products, and synthetic drugs: contributions to understanding snakebite envenomings and their treatment
  • artículo científico
2009

No disponible

Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom
  • artículo científico
2008

No disponible

Snake Venomics of the Lesser Antillean Pit Vipers Bothrops caribbaeus and Bothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of a Heterologous Antivenom
  • artículo científico
2008

No disponible

Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper
  • artículo científico
2008

No disponible

Skin Pathology Induced by Snake Venom Metalloproteinase: Acute Damage, Revascularization, and Re-epithelization in a Mouse Ear Model
  • artículo científico
2008

No disponible

Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations
  • artículo científico
2007

No disponible

Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations
  • artículo científico
2007

No disponible

Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu
  • artículo científico
2007

No disponible

Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines
  • artículo científico
2006

No disponible

Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase
  • artículo científico
2006

No disponible

Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage.
  • artículo científico
2005

No disponible

Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage
  • artículo científico
2005

No disponible

Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells
  • artículo científico
2005
Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy
  • artículo científico
2004

No disponible

Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis
  • artículo científico
2003
Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities
  • artículo científico
2003

No disponible

Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom
  • artículo científico
2003
Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper
  • artículo científico
2002

No disponible

Modulation of the Susceptibility of Human Erythrocytes to Snake Venom Myotoxic Phospholipases A2: Role of Negatively Charged Phospholipids as Potential Membrane Binding Sites
  • artículo científico
2001

No disponible

Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice
  • artículo científico
2001

No disponible

Pathological alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom
  • artículo científico
2001

No disponible

Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage
  • artículo científico
2001
Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper
  • artículo científico
2000
Snake venom metalloproteinases: Their role in the pathogenesis of local tissue damage
  • artículo científico
2000
Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA
  • artículo científico
2000
Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene
  • artículo científico
2000
Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper
  • artículo científico
2000
Bothrops asper snake venom and its metalloproteinase BaP–1 activate the complement system. Role in leucocyte recruitment
  • artículo científico
2000
Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom
  • artículo científico
1999
Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper
  • artículo científico
1998
Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom
  • artículo científico
1998
Isolation and characterization of a myotoxic phospholipase A2 from the venom of the arboreal snake Bothriechis (Bothrops) schlegelii from Costa Rica
  • artículo científico
1997

No disponible

Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice
  • artículo científico
1996

No disponible

Effect of adjuvants on the antibody response of mice to Bothrops asper (Terciopelo) snake venom
  • artículo científico
1996

No disponible

Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom
  • artículo científico
1995

No disponible

Immunological studies on BaH1 and BaPI, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper
  • artículo científico
1995

No disponible