Alberto Alape Giron

Investigador(a)

Alberto Alape Giron

Correo electrónico: ALBERTO.ALAPE@ucr.ac.cr

Categoría Regimen Académico: CATEDRATICO
Grado Académico: DR.
Unidad Base: INSTITUTO CLODOMIRO PICADO

Proyectos
Publicaciones Kérwá

Proyectos

Mostrando 1 proyectos

Núm. de proyecto	Descripción	Unidad de Investigación	Todos DESARROLLO TERMINADO VENCIDO
C1206	RESPUESTA INMUNE CELULAR EN PACIENTES CON COVID19 TRATADOS CON ANTICUERPOS EQUINOS CONTRA PROTEÍNAS RECOMBINANTES DEL SARS-COV-2	Instituto Clodomiro Picado	Vencido

Distinciones

Distinción	Año	Entidad	Ámbito	Descripción
No hay datos disponibles

BECAS

País	Entidad	Año de inicio	Año de término	Descripción
COSTA RICA	UNIVERSIDAD DE COSTA RICA	1900	1988

Publicaciones

Mostrando 33 publicaciones

TÍTULO	TIPO	FECHA	PROYECTO
Aprendizaje cooperativo en un curso de bioquímica: opinión de estudiantesy efecto en su rendimiento académico / Cooperative learning in a Biochemistry course: students opinion and the effect in their academic performance	artículo original		No disponible
Clostridium perfringens Phospholipase C, an Archetypal Bacterial Virulence Factor, induces the Formation of Extracellular Traps by Human Neutrophils	artículo preliminar	2023	C1330
In vitro Characterization of Anti-SARS-CoV-2 Intravenous Immunoglobulins (IVIg) Produced From Plasma of Donors Immunized With the BNT162b2 Vaccine and Its Comparison With a Similar Formulation Produced From Plasma of COVID-19 Convalescent Donors	artículo original	2022	C0198
Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19	artículo original	2021	C0198
High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern	artículo original	2021	C0198
Venoms of Micrurus coral snakes: evolutionary trends in compositional patterns emerging from proteomic analyses	artículo original	2016	B3760
Lemnitoxin, the major component of Micrurus lemniscatus coral snake venom, is a myotoxic and pro-inflammatory phospholipase A2	artículo original	2016	No disponible
Bacterial Sphingomyelinases and Phospholipases as Virulence Factors	artículo original	2016	B1601 B1603 A9503
Membrane-damaging and cytotoxic sphingomyelinases and phospholipases	capítulo de libro	2015	No disponible
Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis	artículo original	2013	No disponible
Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing	artículo original	2011	No disponible
Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae)	artículo original	2011	No disponible
Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic Trend along Crotalus Dispersal in South America	artículo original	2010	No disponible
Impact of Regional Variation in Bothrops asper Snake Venom on the Design of Antivenoms: Integrating Antivenomics and Neutralization Approaches	artículo original	2010	No disponible
Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming	artículo original	2009	No disponible
Phospholipase C and sphingomyelinase activities of the Clostridium perfringens Alfa-toxin	artículo original	2009	No disponible
Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management	artículo original	2009	No disponible
Isolation, characterization and molecular cloning of AnMIP, a new α-type phospholipase A2 myotoxin inhibitor from the plasma of the snake Atropoides nummifer (Viperidae: Crotalinae)	artículo original	2007	A4070
A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C	artículo original	2005	No disponible
Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis	artículo original	2003	A1504 A2036
Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities	artículo original	2003	No disponible
Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A2 homologue	artículo original	2002	No disponible
Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene	artículo original	2000	98287
Elapid venom toxins: multiple recruitments of ancient scaffolds	artículo original	1999	No disponible
Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom	artículo original	1999	89057
Isolation and characterization of a myotoxic phospholipase A2 from the venom of the arboreal snake Bothriechis (Bothrops) schlegelii from Costa Rica	artículo original	1997	No disponible
Development of immunoassays for determination of circulating venom antigens during envenomations by coral snakes (Micrurus species)	artículo original	1997	No disponible
A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus	artículo original	1997	No disponible
Antibody-mediated neutralization and binding-reversal studies on α-neurotoxins from micrurus nigrocinctus nigrocinctus (coral snake) venom	artículo original	1996	No disponible
Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect	artículo original	1994	No disponible
Immunochemical characterization of Micrurus nigrocinctus nigrocinctus venom with monoclonal and polyclonal antibodies	artículo original	1994	No disponible
Electrophoretic and immunochemical studies of Micrurus venoms	artículo original	1994	No disponible
A new method for the detection of phospholipase A2 variants: identification of isozymes in the venoms of newborn and adult Bothrops asper (terciopelo) snakes	artículo original	1988	No disponible