| La importancia de fortalecer la generación y la transmisión de conocimiento científico-tecnológico en Odontología |
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No disponible
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| Neutralización del efceto hemorrágico inducido por veneno Bothrops asper (Serpentes: Viperidae) por extractos de las plantas tropicales |
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No disponible
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| Toxicidad y neutralización de venenos ofidicos peruanos de los géneros Bothrops y Lachesis (Serpentes: Viperidae) |
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No disponible
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| Instituto Clodomiro Picado de Costa Rica: 25° Aniversario/Instituto Clodomiro Picado de Costa Rica: 25° Aniversario |
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No disponible
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| Effects of bleeding in horses immunized with snake venoms for antivenom production |
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No disponible
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| "Viaje hacia el silencio. La historia de una familia costarricense con sordera", de Pedro León Azofeifa. |
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No disponible
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| Production of monovalent anti-Bothrops asper antivenom: development oí immune response in horses and neutralizing ability |
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No disponible
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| Geographic and ontogenic variability in the venom of the neotropical rattlesnake Crotalus durissus: Pathophysiological and therapeutic implications/Geographic and ontogenic variability in the venom of the neotropical rattlesnake Crotalus durissus: Pathophysiological and therapeutic implications |
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No disponible
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| Botrhops ophryomegas Bocourt (Serpentes: Viperidae) en Costa Rica: distribución, lepidosis, variación sexual y cariotipo |
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No disponible
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| Anticoagulant effect of myotoxic phospholipase A2 isolated from the venom of the snake Bothrops asper (Viperidae) |
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No disponible
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| Discovery and optimization of a broadly-neutralizing human antibody against long-chain α-neurotoxins from snakes |
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2023 |
No disponible
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| In vivo neutralization of Myotoxin II, a phospholipase A2 homolog from Bothrops asper venom, using peptides discovered via phage display technology |
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2022 |
No disponible
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| The recovery from the neuroparalysis caused by Micrurus nigrocinctus venom is accelerated by an agonist of the CXCR4 receptor |
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2022 |
No disponible
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| Proteomic and toxicological analysis of the venom of Micrurus yatesi and its neutralization by an antivenom |
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2022 |
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| Half a century of research on Bothrops asper venom variation: biological and biomedical implications |
|
2022 |
No disponible
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| In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom. |
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2022 |
No disponible
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| Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus |
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2021 |
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| High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern |
|
2021 |
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| Assessing a 6-h endpoint observation time in the lethality neutralization assay used to evaluate the preclinical efficacy of snake antivenoms |
|
2021 |
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| Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19 |
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2021 |
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| Métodos de Investigación: destrezas básicas para el trabajo científico en las disciplinas biomédicas |
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2020 |
No disponible
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| A lipidomic perspective of the action of group IIA secreted phospholipase A2 on human monocytes: lipid droplet biogenesis and activation of cytosolic phospholipase A2α |
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2020 |
No disponible
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| An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity |
|
2020 |
No disponible
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| Varespladib (LY315920) and methyl Varespladib (LY333013) abrogate or delay lethality induced by presynaptically-acting neurotoxic snake venoms |
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2020 |
No disponible
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| Novel snakebite therapeutics must be tested in appropriate rescue models to robustly assess their preclinical efficacy |
|
2020 |
No disponible
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| 12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages |
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2020 |
No disponible
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| Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2 |
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2019 |
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| Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920) |
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2019 |
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| Reflexiones desde la academia. Universidad, ciencia y sociedad |
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2019 |
No disponible
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| First look into the venom of Roatan Island´s critically endangered coral snake Micrurus ruatanus: proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom |
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2019 |
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| Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus |
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2018 |
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| Pros and cons of different therapeutic antibody formats for recombinant antivenom development |
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2018 |
No disponible
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| Innovative immunization strategies for antivenom development |
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2018 |
No disponible
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| A novel pentameric phospholipase A2 myotoxin (PophPLA2) from the venom of the pit viper Porthidium ophryomegas |
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2018 |
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| Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms |
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2018 |
No disponible
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| Myotoxin-neutralizing peptides |
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2018 |
No disponible
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| Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: functional profile of hemolytic and non-hemolytic isoforms |
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2018 |
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| Delayed oral LY333013 rescues mice from highly neurotoxic, lethal doses of Papuan Taipan (Oxyuranus scutellatus) venom |
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2018 |
No disponible
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| In vivo neutralization of the dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG monoclonal antibodies |
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2018 |
No disponible
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| A snake venom secreted phospholipase A2 induces foam cell formation depending on the activation of factors involved in lipid homeostasis |
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2018 |
No disponible
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| Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus |
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2017 |
No disponible
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| Geographical variability of the venoms of four populations of Bothrops asper from Panama: Toxicological analysis and neutralization by a polyvalent antivenom |
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2017 |
No disponible
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| Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca |
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2017 |
No disponible
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| Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping |
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2017 |
No disponible
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| Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect |
|
2017 |
No disponible
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| Comparison of the adjuvant activity of emulsions with different physicochemical properties on the antibody response towards the venom of West African carpet viper (Echis ocellatus) |
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2017 |
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| Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead |
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2017 |
No disponible
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| Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis |
|
2016 |
No disponible
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| Hemorrhage Caused by Snake Venom Metalloproteinases: A Journey of Discovery and Understanding |
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2016 |
No disponible
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| Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: A biochemical and immunohistochemical study |
|
2016 |
No disponible
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| Mecanismo de açao dos venenos de cobras corais |
|
2016 |
No disponible
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| Understanding and confronting snakebite envenoming: The harvest of cooperation |
|
2016 |
No disponible
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| High-throughput immuno-profiling of mamba (Dendroaspis) venom toxin epitopes using high-density peptide microarrays |
|
2016 |
No disponible
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| Novel catalytically-inactive PII metalloproteinases from a viperid snake venom with substitutions in the canonical zinc-binding motif |
|
2016 |
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| The need for an integrated approach in confronting snakebite envenoming in Latin America: the relevance of endogenous scientific and technological research |
|
2016 |
No disponible
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| Preclinical evaluation of three polyspecific antivenoms against the venom of Echis ocellatus: Neutralization of toxic activities and antivenomics |
|
2016 |
No disponible
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| Venom of the Coral Snake Micrurus clarki: Proteomic Profile, Toxicity, Immunological Cross-Neutralization, and Characterization of a Three-Finger Toxin |
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2016 |
No disponible
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| Venoms of Micrurus coral snakes: evolutionary trends in compositional patterns emerging from proteomic analyses |
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2016 |
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| Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps). |
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2016 |
No disponible
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| Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom |
|
2016 |
No disponible
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| Metaloproteinasas dependientes de Zinc: Protagonistas centrales en la Fisiopatología de Envenenamientos por Serpientes de la familia Viperidae |
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2016 |
No disponible
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| Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest |
|
2016 |
No disponible
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| Lemnitoxin, the major component of Micrurus lemniscatus coral snake venom, is a myotoxic and pro-inflammatory phospholipase A2 |
|
2016 |
No disponible
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| From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy |
|
2016 |
No disponible
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| Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab0)2 and whole IgG antivenoms |
|
2016 |
No disponible
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| Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii |
|
2016 |
No disponible
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| Evaluation of the preclinical efficacy of four antivenoms, distributed in sub-Saharan Africa, to neutralize the venom of the carpet viper, Echis ocellatus, from Mali, Cameroon, and Nigeria |
|
2015 |
No disponible
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| Antivenomics: a proteomics tool for studying the immunoreactivity of antivenoms |
|
2015 |
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| Phospholipase A2 enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis |
|
2015 |
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| The lethality test used for estimating the potency of antivenoms against Bothrops asper snake venom: Pathophysiological mechanisms, prophylactic analgesia, and a surrogate in vitro assay |
|
2015 |
|
| Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step |
|
2015 |
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| Snakebites are associated with poverty, weather fluctuations, and El Niño |
|
2015 |
No disponible
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| Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score |
|
2015 |
No disponible
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| A Call for Incorporating Social Research in the Global Struggle against Snakebite |
|
2015 |
No disponible
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| Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: identification of key toxin targets for antivenom development. |
|
2015 |
No disponible
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| Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids |
|
2015 |
No disponible
|
| Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis |
|
2015 |
No disponible
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| Índices bibliométricos y revistas de ‘corriente central’: implicaciones para el desarrollo de las ciencias naturales en Costa Rica |
|
2015 |
No disponible
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| First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis |
|
2015 |
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| MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity |
|
2015 |
No disponible
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| Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: Insights from a Model with Extract Administration before Venom Injection |
|
2015 |
No disponible
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| Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms |
|
2015 |
No disponible
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| Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage |
|
2015 |
No disponible
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| Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins |
|
2015 |
No disponible
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| Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil |
|
2015 |
No disponible
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| Antivenomic Characterization of Two Antivenoms Against the Venom of the Taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia |
|
2014 |
No disponible
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| Preclinical efficacy of Australian antivenoms against the venom of the small-eyed snake, Micropechis ikaheka, from Papua New Guinea: An antivenomics and neutralization study |
|
2014 |
|
| Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom |
|
2014 |
No disponible
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| Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo |
|
2014 |
|
| Intravascular hemolysis induced by the venom of the Eastern coral snake, Micrurus fulvius, in a mouse model: Identification of directly hemolytic phospholipases A2 |
|
2014 |
No disponible
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| Omics Meets Biology: Application to the Design and Preclinical Assessment of Antivenoms |
|
2014 |
No disponible
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| Combined venom gland cDNA sequencing and venomics of the New Guinea small-eyed snake, Micropechis ikaheka |
|
2014 |
|
| Current challenges for confronting the public health problem of snakebite envenoming in Central America |
|
2014 |
No disponible
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| Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation |
|
2014 |
|
| Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica |
|
2014 |
No disponible
|
| Two color morphs of the pelagic yellow-bellied sea snake, pelamis platura, from different locations of Costa Rica: snake venomics, toxicity, and neutralization by antivenom |
|
2014 |
|
| Snakebite Envenomingin Latin America and the Caribbean |
|
2014 |
No disponible
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| Anticomplementary Activity of Horse IgG and F(ab’)2 Antivenoms |
|
2014 |
No disponible
|
| A multicomponent strategy to improve the availability of antivenom for treating snakebite envenoming |
|
2014 |
No disponible
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| A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom |
|
2014 |
No disponible
|
| Venomics of new world pit vipers: genus-wide comparisons of venom proteomes across Agkistrodon |
|
2014 |
|
| Critical role of TLR2 and MyD88 for functional response of macrophages to a group IIA-Secreted phospholipase A2 from snake venom |
|
2014 |
No disponible
|
| Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays |
|
2014 |
No disponible
|
| Venomous snakes of Costa Rica: biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics |
|
2014 |
|
| Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: Comparison of their stability in an accelerated test |
|
2014 |
No disponible
|
| The analgesics morphine and tramadol do not alter the acute toxicity induced by Bothrops asper snake venom in mice |
|
2014 |
No disponible
|
| An Asp49 Phospholipase A2 from Snake Venom Induces Cyclooxygenase-2 Expression and Prostaglandin E2 Production via Activation of NF-κB, p38MAPK, and PKC in Macrophages |
|
2014 |
No disponible
|
| Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus |
|
2014 |
No disponible
|
| Understanding structural and functional aspects of PII snake venom metalloproteinases: Characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis |
|
2014 |
No disponible
|
| Role of enzymatic activity inmuscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved? |
|
2014 |
No disponible
|
| Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom |
|
2014 |
|
| Reducing the impact of snakebite envenoming in Latin America and the Caribbean: achievements and challenges ahead |
|
2014 |
No disponible
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| Industrial Production and Quality Control of Snake Antivenoms |
|
2014 |
No disponible
|
| Integrated “omics” profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus |
|
2013 |
No disponible
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| Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A2 myotoxins – distinct mechanisms of action |
|
2013 |
No disponible
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| Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics |
|
2013 |
No disponible
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| Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom |
|
2013 |
No disponible
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| A catalytically-inactive snake venom Lys49 phospholipase A2 homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages |
|
2013 |
No disponible
|
| Intraspecies variation in the venom of the rattlesnake Crotalus simus from Mexico: Different expression of crotoxin results in highly variable toxicity in the venoms of three subspecies |
|
2013 |
No disponible
|
| Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model |
|
2013 |
No disponible
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| The Need for Full Integration of Snakebite Envenoming within a Global Strategy to Combat the Neglected Tropical Diseases: The Way Forward |
|
2013 |
No disponible
|
| New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India |
|
2013 |
No disponible
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| Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and neutralization assays |
|
2013 |
No disponible
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| Antivenom for snakebite envenoming in Sri Lanka: The need for geographically specific antivenom and improved efficacy |
|
2013 |
No disponible
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| Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms |
|
2013 |
No disponible
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| Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture |
|
2013 |
No disponible
|
| Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis |
|
2013 |
No disponible
|
| Role of the animal model on the pharmacokinetics of equine-derived antivenoms |
|
2013 |
No disponible
|
| Using Geographical Information Systems to Identify Populations in Need of Improved Accessibility to Antivenom Treatment for Snakebite Envenoming in Costa Rica |
|
2013 |
No disponible
|
| Why myotoxin-containing snake venoms possess powerful nucleotidases? |
|
2013 |
No disponible
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| Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase |
|
2013 |
No disponible
|
| Phospholipases A2: Unveiling the secrets of a functionally versatile group of snake venom toxins |
|
2013 |
No disponible
|
| Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico |
|
2013 |
No disponible
|
| A Lys49 Phospholipase A2, Isolated from Bothrops asper Snake Venom, Induces Lipid Droplet Formation in Macrophages Which Depends on Distinct Signaling Pathways and the C-Terminal Region |
|
2013 |
No disponible
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| Envenomations by Bothrops and Crotalus Snakes Induce the Release of Mitochondrial Alarmins |
|
2012 |
No disponible
|
| Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica |
|
2012 |
No disponible
|
| Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: Toxicological and taxonomical insights |
|
2012 |
No disponible
|
| Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab0)2] antivenoms, in Bothrops asper bites in Colombia |
|
2012 |
No disponible
|
| Inversión en ciencia, tecnología e innovación: proyectando a Costa Rica |
|
2012 |
No disponible
|
| Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: Role of neurotoxic and procoagulant effects in venom toxicity |
|
2012 |
No disponible
|
| Improving antivenom availability and accessibility: Science, technology, and beyond |
|
2012 |
No disponible
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| Efficacy of IgG and F(ab′)2 Antivenoms to Neutralize Snake Venom-induced Local Tissue Damage as Assessed by the Proteomic Analysis of Wound Exudate |
|
2012 |
|
| Low pH formulation of whole IgG antivenom: Impact on quality, safety, neutralizing potency and viral inactivation |
|
2012 |
No disponible
|
| La situación de los antivenenos liofilizados en América Latina: Aspectos tecnológicos y de salud pública |
|
2012 |
No disponible
|
| Antiplasmodial effect of the venom of Crotalus durissus cumanensis, crotoxin complex and Crotoxin B |
|
2012 |
No disponible
|
| Second generation snake antivenomics: Comparing immunoaffinity and immunodepletion protocols |
|
2012 |
No disponible
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| Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: Keys to understand the variable immune response in horses |
|
2012 |
No disponible
|
| Purification of IgG and albumin from human plasma by aqueous two phase system fractionation |
|
2012 |
No disponible
|
| Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom |
|
2012 |
No disponible
|
| Venom of Bothrops asper from Mexico and Costa Rica: Intraspecific variation and cross-neutralization by antivenoms |
|
2012 |
|
| A Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling |
|
2012 |
No disponible
|
| Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom |
|
2011 |
|
| Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae) |
|
2011 |
No disponible
|
| Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing |
|
2011 |
No disponible
|
| Antivenoms for the treatment of snakebite envenomings: The road ahead |
|
2011 |
No disponible
|
| High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry |
|
2011 |
No disponible
|
| Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenoms |
|
2011 |
|
| Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases |
|
2011 |
|
| Proteomics of Wound Exudate in Snake Venom-Induced Pathology: Search for Biomarkers To Assess Tissue Damage and Therapeutic Success |
|
2011 |
No disponible
|
| Ending the drought: New strategies for improving the flow of affordable, effective antivenoms in Asia and Africa |
|
2011 |
No disponible
|
| Membrane cholesterol modulates the cytolytic mechanism of myotoxin II, a Lys49 phospholipase A2 homologue from the venom of Bothrops asper |
|
2011 |
No disponible
|
| A phospholipase A2 from Bothrops asper snake venom activates neutrophils in culture: Expression of cyclooxygenase-2 and PGE2 biosynthesis |
|
2011 |
No disponible
|
| Desarrollo de las universidades públicas de Latinoamérica: una visión alternativa al modelo economicista de rentabilidad |
|
2011 |
No disponible
|
| Poor regenerative outcome after skeletal muscle necrosis induced by Bothrops asper venom: alterations in microvasculature and nerves |
|
2011 |
|
| A group IIA-secreted phospholipase A2 from snake venom induces lipid body formation in macrophages: the roles of intracellular phospholipases A2 and distinct signaling pathways |
|
2011 |
No disponible
|
| Antivenoms for Snakebite Envenomings |
|
2011 |
No disponible
|
| Venenos de serpientes de la familia Viperidae en América: Bioquímica y fisiopatología. |
|
2011 |
No disponible
|
| Phospholipases A2 From Viperidae Snake Venoms: How do They Induce Skeletal Muscle Damage? |
|
2011 |
No disponible
|
| Envenenamientos por mordeduras de serpientes en América Latina y el Caribe: Una visión integral de carácter regional |
|
2011 |
No disponible
|
| Immune Response Towards Snake Venoms |
|
2011 |
|
| Snake Venomics of African Spitting Cobras: Toxin Composition and Assessment of Congeneric Cross-Reactivity of the Pan-African EchiTAb-Plus-ICP Antivenom by Antivenomics and Neutralization Approaches |
|
2011 |
|
| The struggle of neglected scientific groups: ten years of NeTropica efforts to promote research in tropical diseases in Central America |
|
2011 |
No disponible
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| Proteomic and biological characterization of the venom of the redtail coral snake, Micrurus mipartitus (Elapidae), from Colombia and Costa Rica |
|
2011 |
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| Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management |
|
2011 |
No disponible
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| Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases |
|
2011 |
No disponible
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| Preclinical evaluation of caprylic-acid fractionated IgG antivenom for the treatment of taipan (Oxyuranus scutellatus) envneoming in Papua New Guinea |
|
2011 |
No disponible
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| Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective? |
|
2010 |
No disponible
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| Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa |
|
2010 |
No disponible
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| The Global Snake Bite Initiative: an antidote for snake bite |
|
2010 |
No disponible
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| Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities |
|
2010 |
No disponible
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| Neutralization of Bothrops mattogrossensis snake venom from Bolivia: Experimental evaluation of llama and donkey antivenoms produced by caprylic acid precipitation |
|
2010 |
No disponible
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| The C-terminal region of a Lys49 myotoxin mediates Ca2þ influx in C2C12 myotubes |
|
2010 |
No disponible
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| Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms |
|
2010 |
No disponible
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| Immunochemical and biological characterization of monoclonal antibodies against BaP1, a metalloproteinase from Bothrops asper snake venom |
|
2010 |
No disponible
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| Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom |
|
2010 |
No disponible
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| Antivenomic Assessment of the Immunological Reactivity of EchiTAb-Plus-ICP, an Antivenom for the Treatment of Snakebite Envenoming in Sub-Saharan Africa |
|
2010 |
No disponible
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| Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose |
|
2010 |
No disponible
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| Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic Trend along Crotalus Dispersal in South America |
|
2010 |
No disponible
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| Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows |
|
2010 |
No disponible
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| Backbone Flexibility Controls the Activity and Specificity of a Protein−Protein Interface: Specificity in Snake Venom Metalloproteases |
|
2010 |
No disponible
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| Dr. Clodomiro Picado Twight (1887-1944) |
|
2010 |
No disponible
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| Snakebite envenoming from a global perspective: Towards an integrated approach |
|
2010 |
No disponible
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| Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: Biochemical and toxicological characterization |
|
2010 |
No disponible
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| Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain |
|
2010 |
No disponible
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| Impact of Regional Variation in Bothrops asper Snake Venom on the Design of Antivenoms: Integrating Antivenomics and Neutralization Approaches |
|
2010 |
No disponible
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| Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management |
|
2009 |
No disponible
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| Bothrops asper: Beauty and peril in the Neotropics |
|
2009 |
No disponible
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| Experimental pathology of local tissue damage induced by Bothrops asper snake venom |
|
2009 |
No disponible
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| High-Resolution Crystal Structure of the Snake Venom Metalloproteinase BaP1 Complexed with a Peptidomimetic: Insight into Inhibitor Binding |
|
2009 |
No disponible
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| Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: Report of a workshop |
|
2009 |
No disponible
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| Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism |
|
2009 |
No disponible
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| Hacia una mayor integración de las ciencias naturales y las ciencias sociales: análisis de un caso relacionado con un problema de salud pública |
|
2009 |
No disponible
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| Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming |
|
2009 |
No disponible
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| Stability of equine IgG antivenoms obtained by caprylic acid precipitation: Towards a liquid formulation stable at tropical room temperature |
|
2009 |
No disponible
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| Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom |
|
2009 |
No disponible
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| Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors |
|
2009 |
No disponible
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| Venom, venomics, antivenomics |
|
2009 |
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| The Phospholipase A2 Homologues of Snake Venoms: Biological Activities and Their Possible Adaptive Roles |
|
2009 |
No disponible
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| Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins |
|
2009 |
No disponible
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| Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro |
|
2009 |
No disponible
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| Effects of Bothrops asper snake venom on lymphatic vessels: insights into a hidden aspect of envenomation |
|
2008 |
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| Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis |
|
2008 |
No disponible
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| Secretory phospholipases A2 isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases |
|
2008 |
No disponible
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| Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom |
|
2008 |
No disponible
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| Snake Venomics of the Lesser Antillean Pit Vipers Bothrops caribbaeus and Bothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of a Heterologous Antivenom |
|
2008 |
No disponible
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| Ten simple rules for aspiring scientists in a low-income country |
|
2008 |
No disponible
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| Systemic and local myotoxicity induced by snake venom group II phospholipases A2: Comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue |
|
2008 |
No disponible
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| Computational Biology in Costa Rica: the role of a small country in the global context of bioinformatics |
|
2008 |
No disponible
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| Snake Venomics of Central American Pitvipers: Clues for Rationalizing the Distinct Envenomation Profiles of Atropoides nummifer and Atropoides picadoi |
|
2008 |
No disponible
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| Skin Pathology Induced by Snake Venom Metalloproteinase: Acute Damage, Revascularization, and Re-epithelization in a Mouse Ear Model |
|
2008 |
No disponible
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| Mortality due to snakebite envenomation in Costa Rica (1993–2006) |
|
2008 |
No disponible
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| Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action |
|
2008 |
No disponible
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| Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration |
|
2008 |
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| Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper |
|
2008 |
No disponible
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| Snake Venomics and Antivenomics of the Arboreal Neotropical Pitvipers Bothriechis lateralis and Bothriechis schlegelii |
|
2008 |
No disponible
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| Increased Infectivity of Staphylococcus aureus in an Experimental Model of Snake Venom–Induced Tissue Damage |
|
2007 |
No disponible
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| Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: Evidence of rapid plasma membrane damage and a dual role for extracellular calcium |
|
2007 |
No disponible
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| Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations |
|
2007 |
No disponible
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| Structural and functional properties of BaTX, a new Lys49 phospholipase A2 homologue isolated from the venom of the snake Bothrops alternatus |
|
2007 |
No disponible
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| Strengthening antivenom production in Central and South American public laboratories: Report of a workshop |
|
2007 |
No disponible
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| Role of cyclooxygenases in oedema-forming activity of bothropic venoms |
|
2007 |
No disponible
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| Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu |
|
2007 |
No disponible
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| The snake venom metalloproteinase BaP1 induces joint hypernociception through TNF-α and PGE2-dependent mechanisms |
|
2007 |
No disponible
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| Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations |
|
2007 |
No disponible
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| Pharmacokinetics of whole IgG equine antivenom: comparison between normal and envenomed rabbits |
|
2006 |
No disponible
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| Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase |
|
2006 |
No disponible
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| Calcium plays a key role in the effects induced by a snake venom Lys49 phospholipase A2 homologue on a lymphoblastoid cell line |
|
2006 |
No disponible
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| Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice |
|
2006 |
No disponible
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| Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity |
|
2006 |
No disponible
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| Effect of calcineurin inhibitors on myotoxic activity of crotoxin and Bothrops asper phospholipase A2 myotoxins in vivo and in vitro |
|
2006 |
No disponible
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| Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without β-propiolactone, in the treatment of Bothrops asper bites in Colombia |
|
2006 |
No disponible
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| Confronting the neglected problem of snake bite envneoming: the need for a global partnership |
|
2006 |
No disponible
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| Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines |
|
2006 |
No disponible
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| Activation of cellular functions in macrophages by venom secretory Asp-49 and Lys-49 phospholipases A2 |
|
2005 |
No disponible
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| Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells |
|
2005 |
|
| Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: In vitro and in vivo gene expression analysis of the effects of the toxin |
|
2005 |
No disponible
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| Inhibition of Myotoxic Activity of Bothrops asper Myotoxin II by the Anti-trypanosomal Drug Suramin |
|
2005 |
No disponible
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| Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation |
|
2005 |
No disponible
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| A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C |
|
2005 |
No disponible
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| Anticomplementary activity of equine whole IgG antivenoms: comparison of three fractionation protocols |
|
2005 |
|
| Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity |
|
2005 |
No disponible
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| La investigación en la Universidad de Costa Rica: situación actual y perspectivas |
|
2005 |
No disponible
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| Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa |
|
2005 |
No disponible
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| Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGs |
|
2005 |
|
| Role of TNF-α, IL-1β and IL-6 in the local tissue damage induced by Bothrops asper snake venom: an experimental assessment in mice |
|
2005 |
|
| Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage. |
|
2005 |
No disponible
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| A Lys49 phospholipase A2 homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line |
|
2005 |
No disponible
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| Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment |
|
2005 |
|
| Effects of neutrophil depletion in the local pathological alterations and muscle regeneration in mice injected with Bothrops jararaca snake venom |
|
2005 |
|
| Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage |
|
2005 |
No disponible
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| Inflammation induced by Bothrops asper venom: release of proinflammatory cytokines and eicosanoids, and role of adhesion molecules in leukocyte infiltration |
|
2005 |
No disponible
|
| Feeding behavior and venom toxicity of coral snake Micrurus nigrocinctus (Serpentes: Elapidae) on its natural prey in captivity |
|
2004 |
No disponible
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| Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide |
|
2004 |
No disponible
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| Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops atrox |
|
2004 |
|
| Assessment of the viral safety of antivenoms fractionated from equine plasma |
|
2004 |
No disponible
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| Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA2 from Bothrops asper venom |
|
2004 |
No disponible
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| Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators |
|
2004 |
No disponible
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| Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy |
|
2004 |
No disponible
|
| Membrane independent activation of fibroblast proMMP-2 by snake venom: novel roles for venom proteinases |
|
2004 |
No disponible
|
| Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities |
|
2003 |
No disponible
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| Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants |
|
2003 |
No disponible
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| Snake venom metalloproteinases: structure/function relationships studies using monoclonal antibodies |
|
2003 |
No disponible
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| Efectos locales en el envenenamiento ofídico en América Latina |
|
2003 |
No disponible
|
| Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia |
|
2003 |
|
| Preclinical assessment of the ability of polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced in Costa Rica to neutralize the venoms of North American snakes |
|
2003 |
|
| Polyspecific snake antivenom may help in antivenom crisis |
|
2003 |
No disponible
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| Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity |
|
2003 |
No disponible
|
| A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa |
|
2003 |
No disponible
|
| Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom |
|
2003 |
|
| Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation. |
|
2003 |
No disponible
|
| Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis |
|
2003 |
|
| Intramuscular administration of antivenoms in experimental envenomation by Bothrops asper: comparison between Fab and IgG |
|
2003 |
|
| Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venom |
|
2003 |
No disponible
|
| Comprendiendo los venenos de serpientes: 50 años de investigaciones en América Latina |
|
2002 |
No disponible
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| Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms |
|
2002 |
|
| Functional analysis of DM64, an antimyotoxic protein with immunoglobulin-like structure from Didelphis marsupialis serum |
|
2002 |
No disponible
|
| Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper |
|
2002 |
No disponible
|
| Effect of Preservatives on IgG Aggregation, Complement-activating Effect and Hypotensive Activity of Horse Polyvalent Antivenom Used in Snakebite Envenomation |
|
2002 |
|
| Hemostatic effects induced by Thalassophryne nattereri fish venom: a model of endothelium-mediated blood flow impairment. |
|
2002 |
No disponible
|
| Dissociation of enzymatic and pharmacological properties of piratoxins-I and -III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom |
|
2001 |
No disponible
|
| Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice |
|
2001 |
No disponible
|
| Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage |
|
2001 |
|
| The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms |
|
2001 |
|
| Pathological alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom |
|
2001 |
No disponible
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| Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom |
|
2001 |
No disponible
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| Modulation of the Susceptibility of Human Erythrocytes to Snake Venom Myotoxic Phospholipases A2: Role of Negatively Charged Phospholipids as Potential Membrane Binding Sites |
|
2001 |
No disponible
|
| Effects of chemical modifications of crotoxin B, the phospholipase A2 subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities |
|
2001 |
No disponible
|
| Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo |
|
2001 |
No disponible
|
| Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A(2) homologue and neutralization by two antivenoms |
|
2001 |
|
| Comparison between IgG and F(ab′)2 polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions |
|
2001 |
|
| Systemic cytokine response in children bitten by snakes in Costa Rica |
|
2001 |
No disponible
|
| Myotoxic phospholipases A2 in Bothrops snake venoms: Effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu |
|
2000 |
No disponible
|
| Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom |
|
2000 |
|
| Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene |
|
2000 |
|
| Horse IgG isotypes and cross-neutralization of two snake antivenoms produced in Brazil and Costa Rica |
|
2000 |
|
| Structural and functional characterization of myotoxin I, a Lys49 phospholipase A(2) homologue from Bothrops moojeni (Caissaca) snake venom |
|
2000 |
No disponible
|
| Bothrops asper snake venom and its metalloproteinase BaP–1 activate the complement system. Role in leucocyte recruitment |
|
2000 |
|
| Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper |
|
2000 |
|
| Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties |
|
2000 |
|
| Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica |
|
2000 |
|
| Snake venom metalloproteinases: Their role in the pathogenesis of local tissue damage |
|
2000 |
|
| Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms |
|
2000 |
No disponible
|
| Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA |
|
2000 |
|
| Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper |
|
2000 |
|
| Structural and functional characterization of BnSP-7, a lysine-49 myotoxic phospholipase A2 homologue from Bothrops neuwiedi pauloensis venom |
|
2000 |
No disponible
|
| Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro |
|
1999 |
No disponible
|
| Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom |
|
1999 |
|
| Instituto Clodomiro Picado: Ciencia y Tecnología Endógenas en la Solución de un Problema de la Salud Pública en Centroamérica |
|
1999 |
No disponible
|
| Costa rican international cooperative biodiversity group: using insects and other arthropods in biodiversity prospecting |
|
1999 |
No disponible
|
| Structure of a Lys49-Phospholipase A2 homologue isolated from the venom of Bothrops nummifer (jumping viper) |
|
1999 |
No disponible
|
| Elapid venom toxins: multiple recruitments of ancient scaffolds |
|
1999 |
No disponible
|
| A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms |
|
1999 |
|
| Neutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothı́rops snake venoms |
|
1999 |
No disponible
|
| Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani |
|
1999 |
No disponible
|
| Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom |
|
1999 |
|
| Venom Composition and Diet of the Cantil Agkistrodon bilineatus howardgloydi (Serpentes: Viperidae) |
|
1999 |
No disponible
|
| Envenamiento por mordedura de serpiente en Costa Rica en 1996: Epidemiología y consideraciones clínicas |
|
1999 |
No disponible
|
| Amino acid sequence of a myotoxic Lys49-phospholipase A2 homologue from the venom of Cerrophidion (Bothrops) godmani |
|
1998 |
|
| Inhibition by CaNa2EDTA of local tissue damage induced by Bothrops asper (terciopelo) venom: Application in horse immunization for antivenom production |
|
1998 |
|
| Comparative study of the venoms of three subspecies of Lachesis muta (bushmaster) from Brazil, Colombia and Costa Rica |
|
1998 |
No disponible
|
| Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper |
|
1998 |
|
| Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom |
|
1998 |
|
| Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo) |
|
1998 |
|
| Isolation and characterization of a myotoxic phospholipase A2 from the venom of the arboreal snake Bothriechis (Bothrops) schlegelii from Costa Rica |
|
1997 |
No disponible
|
| Inhibition of the hemorrhagic activity of Bothrops asper venom by a novel neutralizing mixture |
|
1997 |
No disponible
|
| A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus |
|
1997 |
No disponible
|
| Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom |
|
1997 |
No disponible
|
| Snakebite mortality in Costa Rica |
|
1997 |
|
| Immunoglobulin G and F(ab')2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom |
|
1997 |
No disponible
|
| Inhibition of toxic activities of Bothrops asper venom and other crotalid snake venoms by a novel neutralizing mixture |
|
1997 |
No disponible
|
| Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: Comparison with two commercial antivenoms |
|
1997 |
No disponible
|
| Biochemical characterization and pharmacological properties of a phospholipase A2 myotoxin inhibitor from the plasma of the snake Bothrops asper |
|
1997 |
|
| Development of immunoassays for determination of circulating venom antigens during envenomations by coral snakes (Micrurus species) |
|
1997 |
No disponible
|
| Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: effects on enzymatic and pharmacological properties |
|
1997 |
No disponible
|
| Effect of adjuvants on the antibody response of mice to Bothrops asper (Terciopelo) snake venom |
|
1996 |
No disponible
|
| Antibody-mediated neutralization and binding-reversal studies on α-neurotoxins from micrurus nigrocinctus nigrocinctus (coral snake) venom |
|
1996 |
No disponible
|
| A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia |
|
1996 |
No disponible
|
| Characterization of alpha-neurotoxin and phospholipase A2 activities from Micrurus venoms. Determination of the amino acid sequence and receptor-binding ability of the major alpha-neurotoxin from Micrurus nigrocinctus nigrocinctus |
|
1996 |
No disponible
|
| Evaluation of the neutralizing ability of antivenoms for the treatment of snake bite envenoming in Central America |
|
1996 |
No disponible
|
| Biochemical and biological characterization of Ecuadorian pitviper venoms (genera Bothriechis, Bothriopsis, Bothrops and Lachesis) |
|
1996 |
No disponible
|
| In vitro activity of BaH1, the main hemorrhagic toxin of Bothrops asper snake venom on bovine endothelial cells |
|
1995 |
No disponible
|
| Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo) |
|
1995 |
No disponible
|
| Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice |
|
1995 |
No disponible
|
| Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom |
|
1995 |
No disponible
|
| Ability of six Latin American antivenoms to neutralize the venom of mapaná equis (Bothrops atrox) from Antioquia and Chocó (Colombia) |
|
1995 |
No disponible
|
| Evaluación de la capacidad de cuatro antivenenos comerciales para neutralizar el veneno de la serpiente Bothrops asper (terciopelo) de Costa Rica |
|
1995 |
No disponible
|
| Purification and characterization of myotoxin IV, a phospholipase A2 variant, from Bothrops asper snake venom |
|
1995 |
No disponible
|
| Structure of a calcium-independent phospholipase-like myotoxic protein from Bothrops asper venom |
|
1995 |
No disponible
|
| Autocatalytic acylation of phospholipase-like myotoxins |
|
1995 |
No disponible
|
| Phospholipase A2 myotoxins from Bothrops snake venoms |
|
1995 |
No disponible
|
| Skeletal Muscle Necrosis and Regeneration after Injection of BaH1, A Hemorrhagic Metalloproteinase Isolated from the Venom of the Snake Bothrops asper (Terciopelo) |
|
1995 |
No disponible
|
| The ability of specific antivenom and low temperature to inhibit the myotoxicity and neuromuscular block induced by Micrurus nigrocinctus venom |
|
1995 |
No disponible
|
| Phospholipase A2 myotoxins from Bothrops snake venoms [Artículo de revisión] |
|
1995 |
No disponible
|
| Immunological studies on BaH1 and BaPI, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper |
|
1995 |
No disponible
|
| A potent antihemorrhagin in the serum of the non-poisonous water snake Natrix tessellata: isolation, characterization and mechanism of neutralization |
|
1994 |
No disponible
|
| Effect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitro |
|
1994 |
No disponible
|
| Caprylic acid fractionation of hyperimmune horse plasma: description of a simple procedure for antivenom production |
|
1994 |
No disponible
|
| Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect |
|
1994 |
No disponible
|
| Pathological changes induced by BaH1, a hemorrhagic proteinase isolated from Bothrops asper (Terciopelo) snake venom, on mouse capillary blood vessels |
|
1994 |
No disponible
|
| Immunochemical characterization of Micrurus nigrocinctus nigrocinctus venom with monoclonal and polyclonal antibodies |
|
1994 |
No disponible
|
| Activity of hemorrhagic metalloproteinase BaH-1 and myotoxin II from Bothrops asper snake venom on capillary endothelial cells in vitro |
|
1994 |
No disponible
|
| An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies |
|
1993 |
No disponible
|
| Effects on cultured mammalian cells of myotoxin III, a phospholipase A2 isolated from Bothrops asper (terciopelo) venom |
|
1993 |
No disponible
|
| Biological and biochemical activities of Vipera berus (European viper) venom |
|
1993 |
No disponible
|
| Isolation and characterization of synergistic hemorrhagins from the venom of the snake Bothrops asper |
|
1993 |
No disponible
|
| Comparison of the immunogenicity and antigenic composition of ten Central American snake venoms |
|
1993 |
No disponible
|
| Effects of Bothrops asper (terciopelo) myotoxin III, a basic phospholipase A2, on liposomes and mouse gastrocnemius muscle |
|
1993 |
No disponible
|
| Turbidity of hyperimmune equine antivenom: the role of phenol and serum lipoproteins |
|
1993 |
No disponible
|
| Crystallization and preliminary diffraction data of two myotoxins isolated from the venoms of Bothrops asper (Terciopelo) and Bothrops nummifer (jumping viper) |
|
1993 |
No disponible
|
| p-Bromophenacyl bromide modification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2, affects its pharmacological activities |
|
1993 |
No disponible
|
| Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (Terciopelo) |
|
1992 |
No disponible
|
| Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman's pit viper) snake venom |
|
1992 |
No disponible
|
| Effect of Bothrops asper (Fer-De-Lance) snake venom on erythrocyte membrane. A comparative study |
|
1992 |
No disponible
|
| Pathological and biochemical changes induced in mice after intramuscular injection of venom from newborn specimens of the snake Bothrops asper (Terciopelo) |
|
1992 |
No disponible
|
| Experimental myonecrosis induced by the venoms of South American Micrurus (coral snakes) |
|
1992 |
No disponible
|
| Calcium ion independent membrane leakage induced by phospholipase-like myotoxins |
|
1992 |
No disponible
|
| An electrophoretic study on phospholipase A2 isoenzymes in the venoms of Central American crotaline snakes |
|
1992 |
No disponible
|
| A eficácia do antiveneno botrópico-crotálico na neutralização das principais atividades do veneno de Bothrops jararacussu |
|
1992 |
No disponible
|
| Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies |
|
1992 |
No disponible
|
| Quantitation by enzyme-immunoassay of antibodies against Bothrops myotoxins in four commercially-available antivenoms |
|
1991 |
No disponible
|
| Biochemical and pharmacological similarities between the venoms of newborn Crotalus durissus durissus and adult Crotalus durissus terrificus rattlesnakes |
|
1991 |
No disponible
|
| Skeletal muscle degeneration and regeneration after injection of bothropstoxin-II, a phospholipase A2 isolated from the venom of the snake Bothrops jararacussu |
|
1991 |
No disponible
|
| Myotoxin II from Bothrops asper (Terciopelo) venom is a lysine-49 phospholipase A2 |
|
1991 |
No disponible
|
| The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities |
|
1991 |
No disponible
|
| DNase activity in Costa Rican crotaline snake venoms: quantification of activity and identification of electrophoretic variants. |
|
1991 |
No disponible
|
| Neutralization of coral snake Micrurus nigrocinctus venom by a monovalent antivenom |
|
1991 |
No disponible
|
| Degenerative and regenerative changes in murine skeletal muscle after injection of venom from the snake Bothrops asper: a histochemical and immunocytochemical study. |
|
1991 |
No disponible
|
| Effect of storage temperature on the stability of polyvalent antivenom produced in Costa Rica. |
|
1990 |
No disponible
|
| The amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asper |
|
1990 |
No disponible
|
| Equine antibodies to Bothrops asper myotoxin II: isolation from polyvalent antivenom and neutralizing ability. |
|
1990 |
No disponible
|
| Standardization of assays for testing the neutralizing ability of antivenoms |
|
1990 |
No disponible
|
| Ontogenetic changes in the venom of the snake Lachesis muta stenophrys (bushmaster) from Costa Rica |
|
1990 |
No disponible
|
| Isolation of basic myotoxins from Bothrops Moojeni and Bothrops Atrox snake venoms |
|
1990 |
No disponible
|
| Dissociation of enzymatic and toxic activities by the use of antibodies |
|
1990 |
No disponible
|
| South American snake venom proteins antigenically-related to Bothrops asper myotoxins. |
|
1990 |
No disponible
|
| Isolation of a galactose-binding lectin from the venom of the snake Bothrops godmani (Godmann's pit viper). |
|
1990 |
No disponible
|
| Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom |
|
1989 |
No disponible
|
| Desarrollo de la respuesta de anticuerpos anti-fosfolipasa A, en caballos inoculados con veneno para la producción de suero antiofídico polivalente en Costa Rica |
|
1989 |
No disponible
|
| Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica |
|
1989 |
No disponible
|
| Local tissue damage induced by Bothrops snake venoms - A review |
|
1989 |
No disponible
|
| A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo) |
|
1989 |
No disponible
|
| Histopathological and biochemical alterations induced by intramuscular injection of Bothrops asper (terciopelo) venom in mice |
|
1989 |
No disponible
|
| Clodomiro Picado y sus años de formación científica |
|
1989 |
No disponible
|
| An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica |
|
1988 |
No disponible
|
| El suero antiofídico polivalente producido en Costa Rica: Estabilidad y capacidad neutralizante |
|
1988 |
No disponible
|
| Karyotypes of five species of coral snakes (Micrurus) |
|
1988 |
No disponible
|
| Body distribution of Bothrops asper (terciopelo) snake venom myotoxin and its relationship to pathological changes |
|
1988 |
No disponible
|
| A new method for the detection of phospholipase A2 variants: identification of isozymes in the venoms of newborn and adult Bothrops asper (terciopelo) snakes |
|
1988 |
No disponible
|
| Detection of proteins antigenically-related to Bothrops asper myotoxin in crotaline snake venoms |
|
1987 |
No disponible
|
| Neutralización de las actividades tóxicas y enzimáticas de cuatro venenos de serpientes de Guatemala y Honduras por el antiveneno polivalente producido en Costa Rica |
|
1987 |
No disponible
|
| Skeletal muscle necrosis induced by a phospholipase A2 isolated from the venom of the coral snake Micrurus nigrocinctus nigrocinctus. |
|
1987 |
No disponible
|
| Effects of a myotoxic phospholipase A2 isolated from Bothrops asper venom on skeletal muscle sarcoplasmic reticulum |
|
1987 |
No disponible
|
| Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo) |
|
1987 |
No disponible
|
| Immunohistochemical demonstration of the binding of bothrops asper myotoxin to skeletal muscle sarcolemma |
|
1987 |
No disponible
|
| Ability of a polyvalent antivenom to neutralize the venom of Lachesis muta melanocephala, a new Costa Rican subspecies of the bushmaster |
|
1987 |
No disponible
|
| Inflammatory infiltrate in skeletal muscle injected with Bothrops asper venom |
|
1986 |
No disponible
|
| Algunas reflexiones sobre Clodomiro Picado Twight y su contribución al desarrollo de las ciencias médicas y naturales de Costa Rica |
|
1986 |
No disponible
|
| Comparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenom |
|
1986 |
No disponible
|
| Pharmacological activities of a toxic phospholipase A isolated from the venom of the snake Bothrops asper |
|
1986 |
No disponible
|
| Pathogenesis of myonecrosis induced by coral snake (Micrurus nigrocinctus) venom in mice |
|
1986 |
No disponible
|
| Isolation and partial characterization of a myotoxin from the venom of the snake Bothrops nummifer |
|
1986 |
No disponible
|
| Cambios en el patrón electroforético del veneno de cascabela muda (Lachesis muta stenophrys) durante el almacenamiento bajo diferentes condiciones |
|
1985 |
No disponible
|
| Isolation from a polyvalent antivenom of antibodies to a myotoxin in Bothrops asper snake venom |
|
1985 |
|
| Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom |
|
1985 |
No disponible
|
| Mecanismo de acción de miotoxinas aisladas de venenos de serpientes |
|
1984 |
No disponible
|
| Isolation of a myotoxin from Bothrops asper venom: Partial characterization and action on skeletal muscle |
|
1984 |
No disponible
|
| Pathogenesis of myonecrosis induced by crude venom and a myotoxin of Bothrops asper. |
|
1984 |
No disponible
|
| Skeletal muscle regeneration after myonecrosis induced by crude venom and a myotoxin from the snake Bothrops asper (Fer-de-Lance). |
|
1984 |
No disponible
|
| Estudios cariológicos de cinco especies de serpientes costarricenses de la familia colubridae |
|
1984 |
No disponible
|
| La actividad proteolítica de los venenos de serpientes de Costa Rica sobre la caseína |
|
1983 |
No disponible
|
| Estudio comparativo de los venenos de serpiente Cascabel (Crotalus durissus durissus) de ejemplares adultos y recien nacidos |
|
1983 |
No disponible
|
| Local effects induced by coral snake venoms: Evidence of myonecrosis after experimental inoculations of venoms from five species |
|
1983 |
No disponible
|
| Neutralization of local effects of the terciopelo (Bothrops asper) venom by blood serum of the colubrid snake Clelia clelia |
|
1982 |
No disponible
|
| Quantitation of myonecrosis induced by myotoxin a from prairie rattlesnake (Crotalus viridis viridis) venom |
|
1982 |
No disponible
|
| Patogénesis y neutralización de los efectos locales inducidos por el veneno de la serpiente "terciopelo" (Bothrops asper). |
|
1982 |
No disponible
|
| Polimorfismo cromosómico intraespecífico en la serpiente de coral Micrurus nigrocinctus (Ophidia: Elapidae) |
|
1981 |
No disponible
|
| El problema de los efectos hemorrágico y mionecrótico por mordeduras de serpiente en el continente Americano |
|
1980 |
No disponible
|
| Mionecrosis, hemorragia y edema inducidos por el veneno de Bothrops asper en ratón blanco |
|
1980 |
No disponible
|
| Efectos proteolitico, hemorragico y mionecrotico de los venenos de serpientes costarricenses de los generos Bothrops, Crotalus y Lachesis |
|
1980 |
No disponible
|
| Karyotype of the yellow-bellied sea snake, Pelamis platurus |
|
1980 |
No disponible
|
| Estudio comparativo de venenos de ejemplares recien nacidos y adultos de Bothrops asper |
|
1980 |
No disponible
|
| Cariotipos de diez especies de serpientes costarricenses de la familia Viperidae |
|
1979 |
No disponible
|
| Cariotipos de las principales serpientes coral (Elapidae: Micrurus) de Costa Rica |
|
1979 |
No disponible
|
